An autologous stem-cell treatment for patients with damaged heart muscle following an acute myocardial infarction has resulted in improved perfusion, a trend towards improved cardiac function, that was dose dependent, according to US research.
Proximagen Group Plc of the UK has expanded its central nervous system franchise with the purchase of rights to two assets from GlaxoSmithKline Plc that are in development for cognition, neuropathic pain and Parkinson’s disease.
AstraZeneca Plc said it is discontinuing development of the monoclonal antibody, motavizumab, for the prevention of respiratory syncytial virus disease. But it will continue work on the antibody as a treatment for RSV, a respiratory tract infection.
Sanofi-Aventis has announced plans to commit up to $800 million to a new chemistry platform that promises to deliver a class of small molecule drugs against cancer that silence disease-causing proteins. Most conventional drugs bind to their protein targets rather than silence, or shut them down entirely.
Eli Lilly and Co has completed the acquisition of Avid Radiopharmaceuticals Inc, a privately-held company in which its venture capital unit has had an equity stake since 2005. Avid has an imaging agent for detecting amyloid plaque that is poised for review by the FDA.
Merck Serono and the US unit of Sanofi-Aventis SA have signed an agreement to jointly explore new combination therapies against cancer. They will look at combinations of agents that could block specific pathways in cancer cells.
The following is an update of recent European and US regulatory decisions.
Privately-owned NovImmune SA of Geneva, Switzerland has raised an additional CHF 20 million (€15.7 million) from a syndicate led by BZ Bank Aktiengesellschaft to advance its monoclonal antibody development programmes.
The US Food and Drug Administration has recommended that the breast cancer indication be removed from Avastin (bevacizumab), which is used in combination with paclitaxel, because the treatment does not prolong overall survival. However, the European Medicines Agency said it will allow the indication to remain because there is still clinical benefit based on progression free survival.
The following is an update of recent alliance and deal activity among biopharmaceutical companies and research institutions.
H. Lundbeck A/S of Denmark has signed agreements with Zenobia Therapeutics Inc of La Jolla, California and Vernalis Plc of the UK to research inhibitors for a family of kinases relevant to diseases of the central nervous system. Specifically, the Danish company is investigating the Leucine-rich repeat kinase 2 (LRRK2) as a target for a potential treatment for Parkinson’s disease. Lundbeck will collaborate with Zenobia to explore the structure and chemistry of the target using Zenobia’s protein expression and x-ray crystallography technology. In a separate agreement with Vernalis, the two companies will identify candidate compounds that can inhibit LRRK2. Financial terms were not disclosed. LRRK2 is an enzyme that is encoded by the LRRK2 gene. Mutations in this gene represent a risk for Parkinson’s disease. LRRK2 inhibition is potentially neuroprotective as it appears the gene is expressed at high levels in dopamine-producing neurons, Lundbeck said.