Privately-held NovImmune SA of Geneva, Switzerland has announced the start of a proof-of-concept study of a monoclonal antibody intended to neutralise the activity of the chemokine, IP-10, in order to treat patients with primary biliary cirrhosis.
Anticipating the start of Phase 3 trials of a stem-cell therapy for heart failure, Cardio3 BioSciences SA has set up a US subsidiary in Rochester, Minnesota, the home of its minority shareholder – the Mayo Clinic. The trials are set to begin in 2012.
Silence Therapeutics Plc stoutly defended the virtues of RNA interference in presenting its first half-year results and announcing the completion of its management reorganization and downsizing.
Sanofi Pasteur is to investigate an immunological approach to acne prevention and treatment by targeting Propionibacterium acnes factors in inflammation. This will be done in collaboration with the University of California, San Diego.
Vernalis Plc said it has achieved a research milestone in its drug discovery collaboration with H. Lundbeck A/S, triggering a payment of £0.3 million. The UK company is identifying candidate compounds targeting the kinase, LRRK2.
Merck & Co has out-licensed its gene therapy portfolio to a new Finland-based company, FKD Therapies Oy, that was founded in early 2011 to source and develop gene-based medicines. Merck has taken an undisclosed equity stake in the company.
Apogenix GmbH said it has finished recruiting patients for its ongoing Phase 2 study of a new agent for glioblastoma. The experimental treatment is an inhibitor of the CD95 ligand, which is thought to play a growth-promoting role in tumours.
Merck Serono has taken steps to expand its franchise in multiple sclerosis by acquiring exclusive rights to an experimental drug described as a second-generation peptide copolymer. Teva Pharmaceuticals’ Copaxone is also a peptide copolymer.
A supplemental new drug application for the AIDS medicine, maraviroc (Celsentri/Selzentry), has been withdrawn by its developers pending further studies of the drug’s efficacy as a once-daily treatment.
The US Food and Drug Administration has approved two new indications for the osteoporosis drug, Prolia (denosumab), enabling it to be used for cancer treatment-induced bone loss, according to Amgen Inc, the developer.