Mologen AG of Germany is expediting discussions with potential pharmaceutical company partners with a view towards starting a Phase 3 study of its lead product for colorectal cancer next year. The product, MGN1703, is a toll-like receptor 9 agonist.
Biotest AG has confirmed its guidance for higher revenue and a slightly higher operating profit this year despite losses on its Greek government bond holdings and a delay in the expected launch of an immunoglobulin product in the US.
UK stem-cell research has received a boost following a decision by the Wellcome Trust and the Medical Research Council to invest £8 million in a new institute for stem-cell biology and medicine. The institute will be located at the University of Cambridge.
A new allogeneic cell therapy has shown promise in the treatment of venous leg ulcers, a condition caused by persistently high blood pressure in the veins of the legs. Results from a 2b study of the therapy were published online in The Lancet on 3 August 2012.
The US Food and Drug Administration has approved Lucentis (ranibizumab injection) for the new indication of diabetic macular edema, an eye disease that can occur in people with diabetes. The developer is Genentech (Roche).
Roche said that its angiogenesis inhibitor, Avastin (bevacizumab), has shown a significant improvement in progression-free survival in newly diagnosed glioblastoma when added to radiation and temozolomide. Overall survival data are expected in 2013.
4SC AG has been taking scientific advice from regulators about the design of a prospective Phase 3 study of its HDAC inhibitor for liver cancer, resminostat. Pending the conclusion of a partnership, a study could start in the 2013 first half, according to management.
Amgen has stopped a Phase 3 trial of its monoclonal antibody for metastatic pancreatic cancer after the independent data monitoring committee concluded the drug was unlikely to show improved overall survival compared with gemcitabine.
Novo Nordisk A/S, which now claims 25% of the global diabetes market, posted a 17% gain in sales to DKK 37.2 billion (€5 billion) in the 2012 first half year, powered by a 20% increase in local currency sales of synthetic insulins and an 82% rise in sales of Victoza (liraglutide), a glucagon-like peptide-1 analog for Type-2 diabetes.
Paion AG has given further details of its new strategy for growth which will focus on developing and distributing specialised products in anaesthesia. This follows the sale of all remaining rights to desmoteplase, the candidate stroke product that was its lead asset.