Meeting Report: Lessons from the first ATMPs

It is one thing to research and develop an advanced therapy medicinal product (ATMP), but quite another to bring it successfully to market. Among the nine ATMPs approved in Europe since 2009, only five are still on the market.

Country: Germany

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Gates partners with Immunocore

The Bill & Melinda Gates Foundation is to invest up to $40 million in Immunocore Ltd to support the development of the company’s T cell receptor technology (TCR) for infectious disease. The UK company already has partnerships exploring TCRs against cancer.

Country: United Kingdom

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New guselkumab data in plaque psoriasis

New longer-term data from a Phase 3 trial of the drug guselkumab for plaque psoriasis has shown that patients achieved consistent rates of skin clearance following treatment at both 52 and 100 weeks, according to the developer Janssen Research & Development LLC.

Country: United States

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EMA recommends two new cancer drugs

The European Medicines Agency has recommended two new cancer drugs for approval in Europe, each with an entirely different mechanisms of action. The first is a PARP inhibitor for ovarian cancer and the second, a photodynamic therapy for prostate cancer.

Country: United Kingdom

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Genenta raises €7 million in Series B round

The Italian gene therapy company, Genenta Science srl, has raised €7 million in a Series B financing round to support development of a second tumor indication for its technology platform in addition to multiple myeloma. The funding was announced on 13 September.

Country: Italy

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Novo to pay $58.65 million to settle probe

Novo Nordisk A/S has reached an agreement with the US government and several states to pay $58.65 million to settle claims of mis-communication over the risks of Victoza, its glucagon-like peptide-1 (GLP-1) drug for Type 2 diabetes. The settlement was announced on 5 September.

Country: Denmark

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Prostvac trial declared futile

A Phase 3 trial of the Bavarian Nordic A/S candidate vaccine for prostate cancer, Prostvac, has been declared futile based on the results of a preplanned interim analysis. The trial’s independent data monitoring committee is recommending the study be discontinued. 

Country: Denmark

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Kåre Schultz to take charge at Teva Pharmaceutical

Kåre Schultz is set to move to Israel to take the top job at Teva Pharmaceutical Industries Ltd at a time of strategic uncertainty for the generic pharmaceuticals producer. Mr Schultz will be leaving H. Lundbeck A/S in Denmark where he has been chief executive since 2015.

Country: Denmark

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Merck to acquire Rigontec

Merck & Co Inc is to acquire Rigontec GmbH of Germany in order to strengthen its portfolio of immuno-oncology compounds led by pembrolizumab. Rigontec has assets that target the retinoic acid-inducible gene I (RIG-I) pathway, part of the innate immune system.

Country: Germany

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Gene therapy trial featured

A Phase 3 trial of a candidate gene therapy for retinal disorder has been highlighted in The Lancet as a possible standard for future trials of genetic medicines. The trial was conducted by Spark Therapeutics Inc whose therapy, voretigene neparvovec, is under review at the US Food and Drug Administration.

Country: United States

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