Regenerative Medicine

Activists applaud stem cell breakthrough

Advocates of stem-cell research have applauded the recent report that US scientists have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body.

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Location

United States

Cardio3 BioSciences raises €19 million

Cardio3 BioSciences SA, which has an autologous cell therapy for patients with chronic heart failure in the clinic, has raised €19 million in a private placement with existing investors to finance the clinical development of its lead product.

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Location

Belgium

Hormone said to control pancreatic beta-cell proliferation

Researchers at Harvard University have reported the discovery of a hormone, betatrophin, that appears to control the proliferation of beta cells, which are essential in the storage and release of insulin in the human body.

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Location

United States

Tissue Regenix reports on trial

Tissue Regenix Plc of the UK said that a trial of its skin graft in patients with chronic leg ulcers healed wounds in more than half of the patients tested. The trial results are being presented this week at the Symposium on Advanced Wound Care in the US.

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Location

United Kingdom

EMA recommends new ATMP product

The European Medicines Agency is recommending approval of a new advanced therapy medicinal product which is intended for the repair of cartilage defects. The product had been available in some EU countries, but now it will be widely traded.

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Location

United Kingdom

Scripps scientists make new stem cell discovery

Scientists at The Scripps Research Institute in La Jolla, California have discovered an antibody that can trigger the transformation of bone marrow stem cells directly into brain cells – something that reportedly has not been done before.

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Location

United States

TiGenix reports on cell therapy trial in RA

TiGenix NV has reported that a Phase 2a study of its allogeneic stem cell therapy in patients with refractory rheumatoid arthritis had positive six-month safety data. The trial enrolled patients who had failed to respond to at least two biologic therapies.

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Location

Belgium

Series A money for GenSight Biologics

GenSight Biologics, a privately-owned French company, has raised €32 million in a Series A round from a group of venture capital funds to develop a gene replacement therapy for Leber’s hereditary optic neuropathy (LHON), a serious eye disorder.

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Location

France

T-cell therapy works in ALL

A revolutionary T-cell immunotherapy developed by scientists at the University of Pennsylvania in the US has demonstrated a positive result in acute lymphoblastic leukaemia (ALL), an aggressive form of childhood cancer. The results of the treatment, which was administered to two patients aged seven and 10, are scheduled to appear in the 18 April 2013 edition of The New England Journal of Medicine. A summary of the study was released early on 25 March.

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Location

United States

Mesoblast raises A$170 million for cell therapies

Mesoblast Ltd of Australia has raised A$170 million (€136.3 million) in a private placement of its shares with existing and new investors including M&G Investment Management and Capital Research. The monies will fund the company’s cell therapies.

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Location

Australia

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