News

The glucagon-like peptide-1 (GLP-1) analogue semaglutide has demonstrated an ability to promote weight loss in people without diabetes, in some cases up to 13.8%, when combined with diet and exercise. The data comes from a Phase 2 trial comparing semaglutide with liraglutide, another GLP-1 analogue, and with placebo.

Roche’s Genentech has committed funding of $96 million to Affimed NV for rights to the German company’s biologics platform for the production of cancer therapies targeting natural killer (NK) cells in the innate immune system. The platform can generate antibodies directed against NK cells as well as against T cells of the adaptive immune system.

A study in Plos Biology by researchers from the Helmholtz Zentrum München and the Ludwig-Maximilians-Universität München has described a metabolic network in mice that is not controlled by the brain but rather by the ‘circadian clock’ inside muscle cells.

Scientists in Vienna, Austria have used organoid technology to grow brain tumours in the laboratory, enabling them to replicate the process of brain carcinogenesis, potentially making the discovery of new biomarkers and treatments for these cancers easier.

Novartis has reported positive Phase 3 data from a trial investigating a new treatment for breast cancer targeting a protein in the PI3K pathway, a signalling pathway for human cancers. The compound, BYL719 (alpelisib), showed an improvement in progression-free survival.

AstraZeneca Plc’s treatment for chronic obstructive pulmonary disease (COPD), Bevespi Aerosphere, has shown non-inferiority but not superiority, on one respiratory measure in a Phase 3b trial in which it was compared with a similar treatment from GlaxoSmithKline Plc.

On a second respiratory measure, it failed to show non-inferiority.

Novo Nordisk A/S has entered a research alliance with Evotec AG to discover and develop new small molecule therapies for diabetes and obesity, diseases that affect an estimated one billion people worldwide. Financial terms of the agreement weren’t disclosed.

Novo Nordisk A/S has acquired a UK university spin-out with technology for a new generation of insulins that would be released automatically into the bloodstream in response to a rise in blood glucose levels. In principle this would make it easier for people with diabetes to manage their disease and achieve tight control over blood glucose levels.

China-based Zhejiang Tianyu Pharmaceutical Co Ltd has had its regulatory clearance for the supply of the active ingredient valsartan to the European market suspended following an inspection showing the presence of N-nitrosodimethylamine (NDMA), a suspected carcinogen. NDMA is classified as a probable human cardinogen based on the results of laboratory tests.

The private equity group Welsh, Carson, Anderson & Stowe (WCAS) is to acquire Abzena Plc, a service company based in Cambridge UK, that has built up an international business in antibody discovery and chemistry services with subsidiaries in two locations in the US.