News

Drug for genetic disorder

Country
Netherlands

A small molecule drug, Welireg (belzutifan), has been given conditional authorisation by the European Medicines Agency for tumours associated with von Hippel-Lindau disease and previously treated advanced kidney cancer. The opinion, announced on 13 December, expands the availability of the drug to Europe from the US where it was approved in 2021 by the Food and Drug Administration. The developer is Merck & Co Inc which submitted data to the EMA from two clinical studies showing efficacy.

New cell therapy approved

Country
United States

A new cell therapy has been approved by the US Food and Drug Administration to treat paediatric patients from two months of age who experience complications from a stem cell transplant for blood cancer or an immune system disorder. The treatment, Ryoncil (remestemcell-L rknd), is an allogeneic therapy made up from mesenchymal stromal cells and isolated from the bone marrow of healthy adult donors. It is indicated for the treatment of acute graft-versus-host disease in patients undergoing transplants who do not respond to corticosteroids.

Adrenal hyperplasia drug

Country
United States

A treatment for classic congenital adrenal hyperplasia (CAH) has been approved by the US Food and Drug Administration – the first new drug in decades for a genetic disorder involving the adrenal glands. The drug, Crenessity (crinecerfont), is a small molecule to be used as an adjunct to glucocorticoids. In two randomised, placebo-controlled trials in adults and children Crenessity was able to reduce an overproduction of androgen in adults and children relative to the production of cortisol, an essential hormone. This was achieved without the need for high levels of glucocorticoids.

Roche drug misses endpoint

Country
Switzerland

A second candidate drug for Parkinson’s disease has failed to meet the primary endpoint in a clinical study of patients with early-stage disease. The Roche Group announced the results of its Phase 2b PADOVA study on 19 December, only days after UCB SA said its medication for early Parkinson’s disease had failed to show efficacy. Roche said it will continue to evaluate data from the main trial and an ongoing extension study in deciding what to do. The candidate drug, prasinezumab, is a monoclonal antibody designed to bind to alpha-synuclein protein and reduce neuronal toxicity.

Merck in-licenses obesity asset

Country
United States

Merck Inc has entered into a licensing deal with the Chinese pharmaceutical group Hansoh Pharma to gain access to a preclinical obesity asset, bringing it into a field currently dominated by Eli Lilly and Co and Novo Nordisk A/S. The asset, HS-10535, is an oral small molecule glucagon-like peptide-1 receptor agonist.

Parkinson’s drug fails

Country
Belgium

A candidate drug for early-stage Parkinson’s disease has failed to show efficacy at Phase 2a despite having demonstrated promise in earlier studies, the co-developer UCB SA announced on 16 December. The drug, minzasolmin, is a small molecule compound designed to inhibit alpha-synuclein misfolding in the brain. Alpha-synuclein is a normal neuronal protein that regulates synaptic vesicle trafficking. However in Parkinson’s disease it misfolds and aggregates into toxic fibrils.

New York Life takes stake in Andera

Country
France

New York Life Investments, a US money manager and its European affiliate Candriam, have entered a partnership under which New York Life, through its affiliate network, will take a 40% minority stake in Andera Partners, the Paris-based investment group. The goal is to jointly expand their pool of clients. Financial terms of the transaction were not disclosed.  Andera manages €4.3 billion in assets for institutional and private investors. New York Life  has a much deeper portfolio with assets under management of $750 billion.

Noema Pharma receives new finance

Country
Switzerland

The Swiss neuroscience company Noema Pharma AG has received fresh financing from the private equity group EQT Life Sciences in order to advance its lead drug candidate for two rare diseases and its pipeline of other central nervous system disorders. The Series B extension brings total capital raised in the round up to CHF 130 million ($145.7 million). This figure includes earlier contributions from Forbion, Jeito Capital, and Sofinnova Partners, among the venture capital groups. 

Citryll raises funds to target neutrophil traps

Country
Netherlands

Citryll BV, a Dutch biotech, has raised €85 million in a Series B venture capital round to advance a monoclonal antibody drug for two inflammatory diseases by targeting a network of extracellular fibers derived from neutrophils. Neutrophils are the body’s first line of defence against infection. One of their methods of protection is to create neutrophil extracellular traps (NETs), primarily composed of DNA from neutrophils, that can engulf and kill pathogens. But these NETs can also contribute to disease if produced in excess.

Novartis, Vyriad to collaborate on genetic therapies

Country
United States

Novartis is to tap the engineering expertise of Vyriad Inc of the US in order to discover and develop in vivo chimeric antigen receptor (CAR) T cell therapies. Announced on 20 November, the agreement will take cell-based gene therapy technology to a new level by enabling the CAR recombinant protein to be delivered to T cells in their natural environment. This will be done by using a lentiviral delivery system to target and transduce resting T cells and reprogramme them while they are still inside the body. The reprogrammed cells would become potential treatment for patients.