News

Abivax SA reported a pooled clinical remission rate of 16.4% in two Phase 3 trials of its small molecule drug, obefazimod, for ulcerative colitis on 22 July, in one of the largest clinical development programmes for the disease ever conducted, The trials were eight-week induction studies and are being followed up by a maintenance trial which, if positive, will lead to a regulatory filing. Top-line results from the maintenance trial are expected in the second quarter of 2026, the company said. 

Sanofi SA is to expand its portfolio of vaccines to prevent respiratory infections with the acquisition of a UK company pioneering an approach called ‘molecular clamp’ technology. This describes a method for stabilising viral proteins in their native shape, reportedly enabling the immune system to recognise and respond to infections better. Announced on 22 July, the acquisition of UK based Vicebio Ltd expands Sanofi’s portfolio by adding a new modality for targeting respiratory diseases.

Novartis plans to buy back up to $10 billion worth of its shares by the end of 2027 following a robust second quarter and expectations for a higher core operating profit this year. Vas Narasimhan, the chief executive, highlighted the buyback in a presentation on 17 July alongside news of double-digit sales increases for key products and progress in the company’s clinical pipeline. The buy-back, which will reward investors, comes on the heels of a recently completed $15 billion share repurchase that started in 2023 and ended on 1 July.

Sarepta Therapeutics Inc, developer of the gene therapy Elevidys (delandistrogene moxeparvovec) for Duchenne muscular dystrophy, faced a further setback on 18 July after  the US Food and Drug Administration was reportedly poised to stop all shipments of the therapy. This followed the deaths of three patients with the disease. Two of the deaths were reported early in the year and involved young people. The third, disclosed on 18 July, involved a 51-year-old man, according to the Bloomberg news service.

Two Norwegian oncology companies announced a merger on 30 June that will generate cash for drug development and advance a joint portfolio of radiopharmaceuticals. The companies are BerGenBio ASA and Oncoinvent ASA. The merger follows BerGenBio’s decision to discontinue its lead cancer product, bemcentinib, and join forces with Oncoinvent to continue Norway’s innovation in radiopharmaceuticals.

US-based Inovio Pharmaceuticals Inc has strengthened its financial position with a public share offering that is expected to raise $25 million. Announced on 3 July, the proceeds will advance an early clinical pipeline of medicines directed against human papillomavirus-related diseases, cancer, and infectious diseases.

Cosentyx (secukinumab), one of Novartis’ top-selling drugs, has failed to show efficacy in a Phase 3 trial of giant cell arteritis, an autoimmune disease affecting the blood vessels. The trial results were announced on 3 July and represent an unusual setback for a drug that has already been approved for seven immune-mediated inflammatory conditions. Cosentyx inhibits interleukin-17A and was first approved in the US in 2015 for plaque psoriasis. The name of the recent trial was GCAptAIN.

DeepMind Technologies Ltd, also known as Google DeepMind, has unveiled a new artificial intelligence tool that has demonstrated an ability to predict how mutations in human DNA sequences can impact the processes that regulate genes. The tool was described for the first time in the 25 June edition of Nature. Google DeepMind is also the developer of AlphaFold, the AI system for predicting the three dimensional structures of proteins.

Novartis has entered into a four-year partnership with ProFound Therapeutics Inc of the US to explore the vast domain of proteins contained in the human proteome in order to find new targets for cardiovascular medicines. Announced on 26 June, the collaboration will entail an upfront payment of $25 million with potential near-term milestone payments of $750 million for each target selected. ProFound was founded in 2020 by Flagship Pioneering, a Cambridge, US-based venture capital group.

A consortium led by the Danish biotech company, Adaptvac ApS, has received $12.4 million from CEPI (the Coalition for Epidemic Preparedness Innovations) and the EU to design and test a candidate vaccine that could offer broad protection against several filoviruses. Filoviruses are a family of viruses known to cause severe haemorrhagic fever in humans. The vaccine would be used to protect high risk populations, such as healthcare workers, in areas where filovirus outbreaks are most prevalent. These are primarily in Central and East Africa.