The Vienna, Austria company Proxygen GmbH has entered into a multi-year research collaboration and licensing agreement with Merck KGaA to develop molecular glue degrader therapies. This is the second collaboration involving molecular glue agents to be negotiated in recent weeks. In May, Bristol Myers Squibb Co extended a drug discovery partnership with Evotec SE to include molecular glue degraders.
A spin-out of the Dutch medical centre, Amsterdam UMC, has raised €5 million in seed funding to take a new cancer vaccine from preclinical development into human trials. CimCure BV has developed a conjugate vaccine that directly targets the tumour endothelium in order to arrest cancer growth. This reportedly unique mechanism of action was highlighted in a paper published in Nature Communications on 23 May 2022.
A syndicate of international investors has raised $75 million for Code Biotherapeutics Inc, a US company developing genetic medicines using a synthetic DNA delivery platform. The delivery technology is different from the conventional viral vector and is described by its developer as versatile and unimpaired by concerns about immunogenicity.
A Japanese company specialising in advanced therapies has received $30.3 million in Series B funding to advance a programme in tissue and organ repair. LUCA Science Inc is working on a mitochondrial replacement therapy that would restore cellular energy flow in damaged tissues and organs.
Priorix, a vaccine developed by GlaxoSmithKline Plc, has been approved by the US Food and Drug Administration for active immunisation for the prevention of measles, mumps and rubella (MMR) infection in individuals 12 months of age and older. The vaccine is currently licensed in more than 100 countries, including the nations of Europe, Canada, Australia and New Zealand but until now, has not been available in the US.
Bristol Myers Squibb Co is to acquire Turning Point Therapeutics Inc, a US oncology drug developer, in a bid to move ahead of its competitors in the field of treatments for non-small cell lung cancer. It is offering $76 per share of Turning Point’s stock in an all cash transaction valued at $4.1 billion. Turning Point’s lead asset, repotrectinib, is a tyrosine kinase inhibitor targeting the ROS1 gene in lung cancer. It is currently in a late stage clinical development.
A Phase 2 trial of a small molecule treatment for ulcerative colitis failed to meet its primary endpoint of clinical remission in patients due to an apparent treatment interference from corticosteroids, according to the developer Immunic Inc. The treatment, vidofludimus calcium, was being compared with placebo in patients with moderate-to-severe disease.
Minoryx Therapeutics SL of Spain has raised €51 million in order to prepare for the regulatory review and possible market launch of its drug leriglitazone for the rare orphan disease X-linked adrenoleukodystrophy (X-ALD). The company is preparing a marketing authorisation application for the European Medicines Agency and holding pre-registration talks with the US Food and Drug Administration. The EU filing would be directed at treating adult male patients with the X-ALD phenotype adrenomyeloneuropathy (AMN).
Germany-based Immatics NV is to make its cell therapy platform available to Bristol Myers Squibb Co in order to develop a further cohort of immunotherapies for cancer. The collaboration, announced on 2 June, is an expansion of an existing partnership aimed at developing off-the-shelf cell therapies for solid tumours.
Pfizer Inc plans to unwind its holding in the prospective consumer healthcare company, Haleon, once Haleon is publically listed, the US company announced on 1 June. Haleon is a joint venture company set up by GlaxoSmithKline Plc and Pfizer Inc to pool their respective consumer healthcare assets in order to bring greater scale to the business.
GSK has a controlling 68% interest in the business, while Pfizer holds 32%.