GlaxoSmithKline Plc has announced the start of two Phase 3 studies that will evaluate the effectiveness of a new combination therapy for the treatment of patients with BRAF-positive metastatic cutaneous melanoma. The studies will also look at safety.
H. Lundbeck A/S said that its experimental treatment for Alzheimer’s disease, Lu AE58054, met its primary endpoint in a Phase 2 proof-of-concept study of 278 patients with moderate disease already being treated with donepezil. Full data will be disclosed at upcoming medical meetings.
Ensemble Therapeutics Corporation and Genentech (Roche) have entered into a collaboration to discover new drug candidates using the US company’s macrocyclic technology platform. Financial terms were not disclosed.
The Karolinska University Hospital and GE Healthcare Life Sciences have started a joint research collaboration to address some of the issues associated with the manufacture and development of new cell therapies. Financial terms weren’t given.
In line with an expansion of its US business, H. Lundbeck A/S is making its shares available in the US in the form of dollar-denominated American Depositary Receipts (ADRs). Deutsche Bank is acting as the depositary bank for the ADR programme.
The European Commission and the pharmaceutical industry have committed €223.7 million to research new antibiotic medicines in the first of several projects to be carried under the Innovative Medicines Initiative (IMI).
A Phase 3 trial of Nexavar (sorafenib) in patients with advanced, relapsed non-small cell lung cancer has failed to meet its primary endpoint of improving overall survival, according to Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals Inc.
BTG Plc has exceeded a forecast issued as recently as April and reported revenue of £197 million for the year ended 31 March, up by 77% a year earlier. Revenue was boosted by strong sales of the antibody- fragment treatments, CroFab and DigiFab.
GlaxoSmithKline Plc has told shareholders of Human Genome Sciences that its $13 per share cash offer represents “full and fair value” for the company. The tender will close on 7 June. The HGS board has recommended against the offer.
Ablynx NV presented an upbeat report for the first quarter with seven nanobody programmes in clinical development, sharply higher revenue and a cash-flow surplus.