Merck Serono SA has announced the creation of a third spin-out company – this time focused on therapies for Alzheimer’s disease and tau protein-related pathologies. This follows its parent company’s decision to downsize and to close the Geneva office.
Ablynx is set to receive €6.5 million upfront under a new collaboration with Merck & Co to develop and commercialise candidate antibody therapeutics that target a voltage gated ion channel, with an option to develop an antibody against a second target.
Evotec AG and Bayer Pharma AG have entered into a five-year collaboration to develop three clinical candidates for endometriosis, a painful gynecological condition.
The US Food and Drug Administration has approved a new indication for Humira (adalimumab) to include the treatment of moderate-to-severe ulcerative colitis in adults. It is the seventh US approval for the drug which is marketed by Abbott Laboratories.
The US Food and Drug Administration has approved Stivarga (regorafenib), a multi-kinase inhibitor, to treat patients with metastatic colorectal cancer. Developed by Bayer AG, the drug was approved under the agency’s priority review procedure.
UCB SA said that a Phase 2b study of its candidate antibody for rheumatoid arthritis, olokizumab, met its primary endpoint. But there was no improvement in efficacy when the drug was compared with tocilizumab (Actemra).
Swedish Orphan Biovitrum (Sobi) has told analysts that its recombinant clotting factor product for haemophilia B achieved positive results in a Phase 3 trial, paving the way for a regulatory filing in the US in the first half of 2013.
Noxxon Pharma AG of Germany has started a Phase 2a study of an oligonucleotide-based drug in patients with multiple myeloma, a disease that accounts for about 1% of all cancers. The 28-patient, multi-center study is being conducted in Europe.
The US Food and Drug Administration has said it will review its regulatory guidelines and consult experts on clinical trial design in a renewed push to stimulate the development of new antibiotic drugs – a public health priority.
The chief financial officer of Epigenomics AG is to double up as acting chief executive as the company moves to shore up its share price and prepare for a regulatory submission of its lead diagnostic. CFO Thomas Taapken will assume the two jobs on 1 October.