The US Food and Drug Administration has approved Bosulif (bosutinib) a new tyrosine kinase inhibitor from Pfizer Inc for the treatment chronic myelogenous leukaemia (CML) in patients who are resistant to other therapies including imatinib.
Theravectys SAS of France, which is developing vaccines based on lentiviral vector technology, has secured €7.48 million from a group of private French investors. The new funds will help the company develop a candidate therapeutic vaccine for HIV.
Merck Serono SA is spinning out a second new enterprise in connection with the closure of its Geneva, Switzerland office – this time focused on bioinformatics. The new company, Quartz Bio SA, will offer biomarker analysis services to the pharma industry.
The US Food and Drug Administration has approved a new androgen receptor inhibitor, Xtandi (enzalutamide), for patients with late-stage castration-resistant prostate cancer who had previously been treated with docetaxel. Xtandi was given a priority review.
On the heels of a successful share placement in July, Oxford BioMedica Plc is moving its gene therapy and cancer vaccine programmes ahead with a near-term focus on completing the dosing of patients in a Phase 1 study of a gene therapy for ‘wet’ age-related macular degeneration (AMD).
Topotarget A/S of Denmark has engaged ABG Sundal Collier to lead a review of the company’s strategic options that could include a new partnership for its lead product, a merger with an industrial partner or a sale of the company.
Genmab A/S has entered into a licensing deal and equity investment with Johnson & Johnson Inc potentially valued at $1.1 billion for an early-stage antibody that targets CD38, a molecule that is highly expressed on multiple myeloma cells. The deal is the largest partnership in the Danish company’s history.
Eli Lilly and Company has announced a decision to stop Phase 3 development of pomaglumetad methionil for schizophrenia after a futility analysis showed that the second of two studies was unlikely to reach its primary endpoint.
The US Food and Drug Administration has approved a new once-daily combination tablet for HIV-1 infection in treatment-naïve adults that contains two previously approved HIV drugs plus two new ones, providing a complete treatment regime.
Pascal Soriot of Roche is to become the new chief executive of AstraZeneca Plc on 1 October following the retirement on 1 June of David Brennan. Simon Lowth, the acting CEO, will stay in this job until Mr Soriot joins, after which he will continue as CFO.