A Phase 2 study of venetoclax, a new drug for chronic lymphocytic leukaemia (CLL), has shown a clinically meaningful reduction in cancer cells in patients with a specific genetic mutation known as the 17p deletion. The patients all had refractory CLL.
Researchers at the Max Planck Institute for Heart and Lung Research in Germany have identified a regulatory mechanism that could be a factor in the development of high blood pressure, a primary risk factor for many cardiovascular diseases.
Evotec AG increased its revenue by 37% to €55 million in the first half year, helped by favourable exchange rates, milestone payments and fees from pharmaceutical partners for whom it provides services. For the year as a whole, the company expects revenue to grow by 35%.
Merus BV of the Netherlands has secured another legal victory over Regeneron Pharmaceuticals Inc in a battle over intellectual property rights to transgenic mouse technology for the production of therapeutic antibodies.
Kiadis Pharma of the Netherlands has raised an additional €2 million from its initial public offering (IPO) of shares on the Euronext stock exchange in Amsterdam and Brussels following the partial exercise of an over-allotment option.
The Wellcome Trust has awarded $3.84 million to Karuna Pharmaceuticals Inc to further develop a novel treatment for schizophrenia that combines the experimental compound xanomeline with an approved medicine called trospium chloride.
Oxford Biotrans Ltd, a spin-out of the University of Oxford, has received £2.5 million in a Series A funding round to commercialise an enzyme technology that has application to soft drinks and confectionary as well as to pharmaceuticals.
France-based TxCell SA has raised €8 million in a private share placement to support development of its two lead cell therapy products, the first of which is in a Phase 2b study in patients with refractory Crohn’s disease. The funds will also support general R&D and manufacturing activities.
Evotec AG has deepened its commercial ties with Sanofi SA with an agreement to develop a beta cell replacement therapy for people with diabetes. The German company is already working with Harvard University on beta cell technology.
Santhera Pharmaceuticals Holding AG has raised CHF 27.7 million (€25.79 million) from new and existing investors for the anticipated launch of Raxone, a product for the treatment of Leber’s Hereditary Optic Neuropathy (LHON), an inherited form of vision loss.