A new gene therapy developed by the San Raffaele Telethon Institute for Gene Therapy together with GlaxoSmithKline Plc, has been given a positive review by the European Medicines Agency. If approved by the European Commission, it will only be the second gene-based product to reach the market in the west.
Milan-based Genenta Science, which has an experimental gene therapy for delivering interferon to tumours, has signed a multi-year manufacturing agreement with MolMed SpA in preparation for the start of clinical trials of a gene therapy for multiple myeloma.
Following a review of its staff disciplinary board, the Karolinska Institutet (KI) announced on 23 March that it had dismissed Paolo Macchiarini, a surgeon who is the focus of an investigation over alleged misconduct involving a novel trachea replacement procedure.
GlaxoSmithKline Plc has signed an agreement with a service company in Germany to gain access to technology for industrialising cell and gene therapies. The two parties will also discover new chimeric antigen-receptor T (CAR T) cell therapies.
Scientists at Michigan State University have described a new type of stem cell following laboratory experiments with mice. They say this could lead to new tools for studying birth defects and other reproductive problems.
The Swedish government announced on 3 March that it is asking a nominating committee to propose new board members for the Karolinska Institutet – the latest twist in a long-running investigation into the research and clinical activities of the visiting professor and surgeon Paolo Macchiarini.
Baxalta Inc has entered the gene editing field with an agreement to work with Precision BioSciences on cancer therapies using engineered immune cells. The collaboration was announced a little more than a month after Baxalta agreed to be acquired by Shire Plc in a deal valued at $32 billion.
A project aimed at improving the properties of adeno-associated viral (AAV) vectors for use in gene therapy has been launched in the UK by Cobra Biologics Ltd, a contract research group, and the Center for Process Innovation, a UK government funded entity.
UK-based Oxford BioMedica Plc is raising £8.1 million with a fully underwritten share placement to finance the expansion of its lentiviral vector manufacturing capacity and advance the clinical development of its gene therapy portfolio.
After discovering a way to produce insulin-producing beta cells from stem cells, US scientists have now shown that they can encapsulate these cells in an alginate and safely transplant them into mice. Moreover, the transplanted cells were shown to produce insulin and maintain blood glucose levels in the mice for 174 days.