Regenerative Medicine

Celgene Corp, which only a year ago entered a 10-year collaboration with Juno Therapeutics, has now invested in Jounce Therapeutics Inc which has different technology for stimulating the immune system to fight cancer.

Juno Therapeutics Inc has acquired a Boston, Massachusetts, US biotech company with technology that can potentially disrupt immunosuppressive pathways in the tumour microenvironment of certain cancers. This fits in with its technology for engineering T cells to fight cancer.

Nextech Invest AG, a Zurich, Switzerland-based, oncology fund manager, has closed its fourth fund, Nextech Oncology Fund IV, with an investment of $64 million. The funds were supplied by limited partners based in the US, Europe and Asia.

Cell Medica Ltd has completed another stage of its strategy for developing immunotherapies for solid tumours with the acquisition of Delenex Therapeutics AG, an antibody specialist based in Switzer

TiGenix NV has decided to withdraw ChondroCelect, its autologous product for knee repair, from the market due to lack of sales. The product was approved for marketing in 2009, but has not been reimbursed in ‘key European countries,’ the company said on 5 July.

Mesoblast Ltd is to do an early interim analysis of a Phase 3 trial of its cell therapy for heart failure in order to take a strategic view of the programme’s future. The analysis will take place in the first quarter of 2017, the Australian company announced on 1 July.

TiGenix NV has secured a development and commercialisation deal for a late-stage cell therapy for a Crohn’s disease indication with Takeda Pharmaceutical Company Ltd, generating an immediate upfront payment of €25 million while retaining rights to the product in the US.

The US Food and Drug Administration has put a clinical hold on a Phase 2 trial of a new immunotherapy developed by Juno Therapeutics Inc after two patients died in early July. A third patient had previously died at the end of May.

As gene editing technologies gain more traction, companies producing the new technologies are attracting more money from investors. One such company is CRISPR Therapeutics of Switzerland that has a number of preclinical projects investigating gene editing for therapeutic use.

A UK-based gene therapy company, Freeline Therapeutics, has received a third investment from the UCL Technology Fund, which supports research from University College London. The fund is managed by Albion Ventures in collaboration with UCL Business, the university’s technology transfer office.