H. Lundbeck A/S said that its experimental treatment for Alzheimer’s disease, Lu AE58054, met its primary endpoint in a Phase 2 proof-of-concept study of 278 patients with moderate disease already being treated with donepezil. Full data will be disclosed at upcoming medical meetings.
Ensemble Therapeutics Corporation and Genentech (Roche) have entered into a collaboration to discover new drug candidates using the US company’s macrocyclic technology platform. Financial terms were not disclosed.
In line with an expansion of its US business, H. Lundbeck A/S is making its shares available in the US in the form of dollar-denominated American Depositary Receipts (ADRs). Deutsche Bank is acting as the depositary bank for the ADR programme.
A Phase 3 trial of Nexavar (sorafenib) in patients with advanced, relapsed non-small cell lung cancer has failed to meet its primary endpoint of improving overall survival, according to Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals Inc.
BTG Plc has exceeded a forecast issued as recently as April and reported revenue of £197 million for the year ended 31 March, up by 77% a year earlier. Revenue was boosted by strong sales of the antibody- fragment treatments, CroFab and DigiFab.
GlaxoSmithKline Plc has told shareholders of Human Genome Sciences that its $13 per share cash offer represents “full and fair value” for the company. The tender will close on 7 June. The HGS board has recommended against the offer.
Ablynx NV presented an upbeat report for the first quarter with seven nanobody programmes in clinical development, sharply higher revenue and a cash-flow surplus.
Cytos Biotechnolgy AG has completed a major portion of a planned CHF 37 million (€30.8 million) equity and debt financing that will give it the resources to conduct a global, multi-centre Phase 2b study of its lead asthma product, CYT003.
GlaxoSmithKline Plc has announced an agreement to fully acquire Cellzome, a specialist in proteomics technology, for £61 million in cash. GSK currently owns 19.98% of the company which is based in Cambridge, UK and Heidelberg, Germany.
H. Lundbeck A/S said that top-line results from three recently completed Phase 3 trials of its investigational drug for major depressive disorder, Lu AA21004, showed statistically significant reductions in depression symptoms in patients.