Desmoteplase, one of the few new therapies under development for patients suffering from stroke, has failed to show efficacy in the first of two Phase 3 clinical trials. The developer, H. Lundbeck A/S, said it will seek advice on the way forward.
A monoclonal antibody being developed by GlaxoSmithKline Plc and Genmab A/S for the treatment of patients with chronic lymphocytic leukaemia (CLL) has failed to meet its primary endpoint of progression-free survival in a small subset of patients with the disease.
Eisai Co Ltd said that real-world data for its epilepsy drug Fycompa (perampanel) show that the treatment is “generally effective and well tolerated” in a variety of patient populations including those with highly refractory epilepsy and comorbidities.
A Phase 3 study of the checkpoint inhibitor nivolumab in patients with advanced melanoma has been stopped early because of evidence that the antibody treatment was achieving superior overall survival compared with the control arm which was chemotherapy.
A nanoparticle designed to treat soft tissue sarcoma has passed its first hurdle with the successful conclusion of a Phase 1 study in patients with the disease. The developer, Nanobiotix SA, plans to position the product alongside radiotherapy as a treatment for patients with locally advanced sarcoma for whom few treatment options exist.
A Phase 3 trial of the antibody therapeutic Cyramza (ramucirumab) has failed to reach its primary endpoint of overall survival in patients with liver cancer. The trial was comparing Cyramza plus best supportive care to placebo plus best supportive care as a second-line therapy.
Novartis has reported that patients with polycythemia vera, a type of blood cancer, showed an improvement in their condition compared with the best available therapy following treatment with the JAK inhibitor Jakavi (ruxolitinib).
An experimental treatment combining the drug olaparib, which blocks DNA repair, with the blood vessel inhibitor cediranib showed a near doubling of progression-free survival in patients with ovarian cancer, according to the National Cancer Institute (NCI).
Roche said that results from a Phase 1 open-label study of its checkpoint inhibitor MPDL3280A shrank tumours in 43% of people with a specific type of metastatic bladder cancer. The data was disclosed at the American Society of Clinical Oncology meeting in Chicago on 31 May.
Santhera Pharmaceuticals Holding AG of Switzerland has reported further positive data from a Phase 3 trial of a new treatment for Duchenne Muscular Dystrophy (DMD), a genetic disease that causes severe degeneration of the muscle.