Using a combination of human neural stem cells and 3K3A-APC, a recombinant variant of human activated protein C, researchers have been able to dramatically increase the production of nerve cells in mice with stroke-induced brain damage. The findings were reported on 22 August 2016 in Nature Medicine.
A review of patients who had experienced a stroke and were treated with an experimental stem cell therapy has shown the therapy to be safe and linked to improved neurological function. Data from a two-year follow-up of the patients were published in The Lancet on 20 August.
Adaptimmune Therapeutics Plc said it is ready to respond to the Food and Drug Administration’s partial hold on its proposed pivotal study of a T cell therapy for treating a rare cancer of connective tissue called myxoid round cell liposarcoma.
Celgene Corp, which only a year ago entered a 10-year collaboration with Juno Therapeutics, has now invested in Jounce Therapeutics Inc which has different technology for stimulating the immune system to fight cancer.
Juno Therapeutics Inc has acquired a Boston, Massachusetts, US biotech company with technology that can potentially disrupt immunosuppressive pathways in the tumour microenvironment of certain cancers. This fits in with its technology for engineering T cells to fight cancer.
Nextech Invest AG, a Zurich, Switzerland-based, oncology fund manager, has closed its fourth fund, Nextech Oncology Fund IV, with an investment of $64 million. The funds were supplied by limited partners based in the US, Europe and Asia.
Cell Medica Ltd has completed another stage of its strategy for developing immunotherapies for solid tumours with the acquisition of Delenex Therapeutics AG, an antibody specialist based in Switzer
TiGenix NV has decided to withdraw ChondroCelect, its autologous product for knee repair, from the market due to lack of sales. The product was approved for marketing in 2009, but has not been reimbursed in ‘key European countries,’ the company said on 5 July.
Mesoblast Ltd is to do an early interim analysis of a Phase 3 trial of its cell therapy for heart failure in order to take a strategic view of the programme’s future. The analysis will take place in the first quarter of 2017, the Australian company announced on 1 July.
TiGenix NV has secured a development and commercialisation deal for a late-stage cell therapy for a Crohn’s disease indication with Takeda Pharmaceutical Company Ltd, generating an immediate upfront payment of €25 million while retaining rights to the product in the US.