Pevion Biotech AG said that data from an ongoing first-in-human trial of a therapeutic vaccine against Candida in healthy volunteers elicited high levels of specific antibodies and a 100% mucosal immune response rate.
A pivotal Phase 3 trial of teriflunomide, a new oral medication for multiple sclerosis, has shown that the drug significantly reduced relapse rates and disability progression, compared with placebo, according to an article in the New England Journal of Medicine.
A team of European researchers has reported on a new epigenetic approach for the treatment of mixed lineage leukaemia (MLL), an aggressive form of cancer which is thought to account for up to eight out of 10 cases of the disease in children.
The European Commission has allocated €30 million to a collaboration of academic institutions and companies to investigate new immunisation technologies for the next generation of vaccines. The project comes under Framework Programme 7 (FP7).
Researchers at Children’s Hospital Boston have reported that a pathway that is activated in cancer appears to play a role in metabolic diseases like Type 2 diabetes. The findings are reported in the 30 September 2011 issue of the journal, Cell.
A Paris-based life science company, Nanobiotix SA, has received clearance to start a Phase 1 safety study of a new nanoproduct in patients with soft-tissue sarcoma. The product has been classified as a device in Europe, but as a drug in the US.
Roche and its partner, ImmunoGen Inc, said Phase 2 data for their antibody-drug conjugate, T-DM1, in patients with metastatic breast cancer showed better progression-free survival than those on trastuzumab and chemotherapy.
Scientists from the Roche group have reported generating the first draft genome sequence of the cynomolgus monkey, Macaca fascicularis, the most frequently used nonhuman primate in drug safety studies.
Privately-held NovImmune SA of Geneva, Switzerland has announced the start of a proof-of-concept study of a monoclonal antibody intended to neutralise the activity of the chemokine, IP-10, in order to treat patients with primary biliary cirrhosis.
Anticipating the start of Phase 3 trials of a stem-cell therapy for heart failure, Cardio3 BioSciences SA has set up a US subsidiary in Rochester, Minnesota, the home of its minority shareholder – the Mayo Clinic. The trials are set to begin in 2012.