Dupixent (dupilumab) has delivered positive results in a Phase 3 trial involving adolescents with moderate-to-severe atopic dermatitis. The drug is already approved for the same disease in adults and is the first biologic to show a benefit in this patient group.
NOXXON Pharma NV has reported a promising response from a patient with metastatic pancreatic cancer to its RNA oligonucleotide drug that is intended to fight cancer by targeting the tumour microenvironment. The company gave the update on 16 May at the BioEquity Europe conference in Belgium.
AstraZeneca Plc is to use organ-on-chip technology to test drug compounds for safety and efficacy under a new collaboration with the Boston, Massachusetts, US company Emulate Inc. Emulate will co-locate scientists within AstraZeneca’s laboratories in the UK where the chips will be tested across the AZ pipeline.
AstraZeneca Plc expects to return to growth in 2018 as new oncology, diabetes and cardiovascular products boost group sales, offsetting the loss of market share for the statin Crestor which faces generic competition in Europe and Japan.
AstraZeneca Plc’s antibody drug for chronic obstructive pulmonary disease (COPD), Fasenra (benralizumab), has failed to meet its primary endpoint in the first of two Phase 3 trials of patients with the disease.
H. Lundbeck A/S recorded double-digit growth for its portfolio of new drugs for depression and schizophrenia in the first quarter, offsetting the loss of sales arising from generic competition. Group revenue for the quarter was DKK 4.6 billion (€615.4 million), up by 9% from a year earlier.
An unusual combination of events drove revenue at Genmab A/S up by DKK 430 million to DKK 681 million (€91.4 million) in the first quarter, for an increase of 171% compared with a year earlier. Operating income consequently rose to DKK 324 million from DKK 46 million the previous year.
A Phase 3 trial evaluating a combination of the checkpoint antibody Tecentriq (atezolizumab) and the kinase inhibitor Cotellic (cobimetinib) in patients with metastatic colorectal cancer failed to meet its primary endpoint of overall survival, Roche announced on 10 May.
Evotec AG ended the first quarter confidently predicting that it will achieve double-digit revenue and profit growth this year largely due to the expansion of its global business following the acquisition of Aptuit LLC in 2017.
Abcam Plc has decided not to pursue a proposed offer for Horizon Discovery Group Plc having been rebuffed by the gene-editing company, which is based in Cambridge, UK. Abcam is a pharmaceutical services company, also based in Cambridge.