Novartis is to acquire MorphoSys AG for €2.7 billion in cash in order to gain access to pelabresib, a late-stage drug for the treatment of myelofibrosis, a blood cancer caused by genetic abnormalities in bone marrow stem cells. The deal, announced on 5 February, unites two companies with a long history of collaboration in the development of antibody therapeutics.
Sanofi SA plans to generate more than €10 billion in sales from the launch of new pharmaceuticals by 2030 as part of a restructuring outlined by Paul Hudson, the chief executive in 2023. Updating the plans on 1 February, Mr Hudson said that Sanofi is on track to complete development of 12 new medicines, of which two are indicated for multiple sclerosis and one for atopic dermatitis. At the same time, the company is moving ahead with plans to spin out its consumer healthcare business in order to focus exclusively on biopharmaceutical and vaccine development.
The Roche Group reported sales of CHF 58.7 billion ($68.6 billion) in 2023, a decline of 7% from a year earlier in Swiss francs. At constant exchange rates however, the results showed a small 1% rise. The decline reflected the absence of sales for Covid-19 products in the most recent period – a reflection of the global recovery from the pandemic. During 2023, Roche also faced biosimilar competition for three of its legacy products – the cancer medicines Herceptin, Avastin and Rituxan. Rituxan is also approved for autoimmune diseases.
Novartis completed the spin-out of its Sandoz generics and biosimilars business in 2023, ending the year with sales of $45.4 billion from continuing operations which consist entirely of proprietary medicines. On 31 January, Vas Narasimhan, the chief executive, restated the company’s goal of focusing on four therapeutic areas in the future. He also singled out four countries where the company will concentrate its marketing efforts. They are the US, China, Germany and Japan.
GSK Plc ended 2023 with a pipeline of 71 vaccines and specialty medicines in clinical development and a forecast for sales of more than £38 billion by 2031 – an upgrade from earlier financial projections. Underlying the forecast are plans for the launch of at least 12 new products from 2025. These are vaccines and medicines in development for infectious diseases, HIV, respiratory diseases and oncology.
IMU Biosciences Ltd, a two-year old UK company, has raised £11.5 million from private investors to create a map of the human immune system using artificial intelligence. The goal is be able to monitor the presence of immune disorders early and guide the development of targeted drugs, also known as precision medicines. The Series A financing was announced on 24 January and led by Moulton Ventures Plc. It also included LifeX Ventures and several individuals.
Biogen Inc is to discontinue the development and commercialisation of Aduhelm (aducanumab), its monoclonal antibody treatment for Alzheimer’s disease in order to direct resources towards newer treatment types. Developed with Eisai Co Ltd, Aduhelm was given an accelerated approval by the US Food and Drug Administration on 7 June 2021 on the basis of data showing a reduction of beta-amyloid plaque in patients.
MetrioPharm AG, a Swiss biotech company, has reported positive results from a trial of its small molecule immune modulator in patients hospitalised with Covid-19. The Phase 2a study showed that the drug, MP1032, was effective when administered with a standard of care and delivered lower mortality compared with patients receiving a placebo and standard of care. According to the company, the results showed that MP1032 is comparable to remdesivir (Veklury), an approved antiviral, with additional safety benefits.
BlueRock Therapeutics LP has exercised an option and gained exclusive rights to a cell therapy derived from induced pluripotent stem cells (iPSC) for the treatment of primary photoreceptor diseases. The product, OpCT-001, was developed in collaboration with Fujifilm Cellular Dynamics Inc, a manufacturer of human iPSCs and iPSC-derived cells, and Opsis Therapeutics LLC.
Healthcare professionals are being advised to monitor patients and clinical trial participants who receive treatment for cancer with a chimeric antigen receptor (CAR) T cell therapy for the risk of secondary malignancies. In a commentary in The New England Journal of Medicine on 25 January, Nicole Verdun and Peter Marks write that while secondary cancers from these medicines appear to be relatively rare, they need to be identified. Drs Verdun and Marks are both senior officials at the US Food and Drug Administration.