News

Amgen to acquire Horizon Therapeutics

Monday 12 December 2022
Country
United States

A competition between US and French multinationals for ownership of Horizon Therapeutics Plc ended on 12 December with an all-cash offer of $27.8 billion from Amgen Inc for the Ireland-based company. The deal value is the largest healthcare merger of 2022, according to The Wall Street Journal. Sanofi SA, which also held talks with Horizon, dropped out of the discussions saying that the target company’s price expectations were too high.

Phase 3 lung cancer trial fails

Monday 12 December 2022
Country
France

A Phase 3 trial of a small molecule drug designed to treat patients with metastatic non-small cell lung cancer failed to meet its primary endpoint of overall survival, the sponsor Ipsen SA announced on 8 December. Cabozantinib was being investigated in 366 patients with both squamous and non-squamous non-small cell lung cancer whose disease had progressed after treatment with a checkpoint inhibitor and chemotherapy.

Positive data for bimekizumab

Saturday 10 December 2022
Country
Belgium

Belgium-based UCB SA has reported positive Phase 3 data for its monoclonal antibody bimekizumab in hidradenitis suppurativa, a chronic inflammatory skin disease that is estimated to affect about one percent of the population in countries where the disease has been identified. Data from the two studies is expected to form the basis of global regulatory applications starting in the third quarter of 2023.

C4XD secures deal with AstraZeneca

Friday 9 December 2022
Country
United Kingdom

C4X Discovery Holdings Plc of the UK has secured a licensing deal with AstraZeneca Plc to apply its small molecule drug discovery technology to identify new treatments for inflammatory and respiratory diseases. The initial plan is to develop a product to treat chronic obstructive pulmonary disease (COPD).

New partnership for Cancer Research Horizons

Sunday 4 December 2022
Country
United Kingdom

Cancer Research Horizons, a division of the UK charity Cancer Research UK, is to work with the Karolinska Institutet over the next five years to identify new opportunities for cancer treatments and move these projects forward through industrial partnerships.

FDA approves first faecal microbiota product

Thursday 1 December 2022
Country
United States

The first faecal transplant therapy derived from the gut microbiome of healthy donors was approved by the US Food and Drug Administration on 30 November, paving the way for regulatory reviews of other products in the sector. The therapy, Rebyota, was developed by Ferring Pharmaceuticals Inc and approved for the prevention of recurrent Clostridioides difficile infection, a potentially life-threatening disease.

AstraZeneca to acquire Neogene Therapeutics

Tuesday 29 November 2022
Country
Netherlands

AstraZeneca Plc is to acquire a Dutch company with technology for developing T cell therapies for cancer which target antigens specific to a patient’s tumour. The company, Neogene Therapeutics Inc, was founded in Amsterdam, the Netherlands in 2018 and has a pipeline of candidate therapies that consist of engineered T cells equipped with receptors targeting tumour-specific antigens, also known as neoantigens.

Launch of FundaMental Pharma

Sunday 27 November 2022
Country
Germany

A new German neuroscience company was formally launched in Heidelberg on 17 November with plans to develop small molecule drugs for the treatment of neurodegenerative diseases including amyotrophic lateral sclerosis and Huntington’s disease. FundaMental Pharma GmbH has received €10 million in seed financing from a consortium led by BioGeneration Ventures and Thuja Capital of the Netherlands and High-Tech Gründerfonds in Germany.

CatalYm raises new capital

Sunday 27 November 2022
Country
Germany

CatalYm GmbH has closed a Series C financing round, raising €50 million to support development of a therapy directed at the immune system for cancer. The Munich, Germany  company has a candidate monoclonal antibody engineered to neutralise the tumour-produced growth differentiation factor-15 (GDF-15). GDF-15 acts as a regulator of immune cell activation and as an inhibitor of immune cell infiltration into the tumour tissue.

Merck to acquire Imago

Sunday 27 November 2022
Country
United States

Merck & Co Inc is to acquire Imago BioSciences Inc, a clinical-stage biopharmaceutical company, for $36 per share in cash in order to strengthen its presence in haematology. The deal, valued at $1.35 billion, is expected to close in the first quarter of 2023. It will be one of the first big transactions executed by the company’s new chief executive Robert Davis, who has succeeded Kenneth Frazier.