GlaxoSmithKline Plc expects to deliver sales growth of 5-7% at constant exchange rates this year and a double-digit increase in adjusted operating profit as it repositions itself as a pure biopharmaceutical enterprise. This will follow the demerger of its jointly-owned consumer healthcare business at mid-year. GSK owns 68% of the business, while Pfizer Inc has 32%.
Dupixent and a group of other specialty care products lifted sales of Sanofi SA in 2021 offsetting declines for legacy cardiovascular and diabetes products. At the same time, the company refreshed its portfolio with three acquisitions in the fourth quarter. Group turnover was €37.76 for the year, up by 4.8% from 2020. The increase was 7.1% when calculated using constant exchange rates. Sales of Dupixent, a treatment for asthma and other auto-immune diseases, amounted to €5.25 billion, up by 52.7% from the previous year.
The Roche Group reported sales of CHF 62.8 billion ($68.12 billion) in 2021, a rise of 8% from a year earlier and largely driven by brisk demand for its Covid-19-related diagnostic products. Diagnostic sales increased by 29% during the year. By contrast, the pharmaceutical division, which accounts for 72% of group turnover, reported a sales increase of just 1%. Measured in constant exchange rates, this increase was 3%.
Novartis saw its profit margin expand in 2021 as operating expenses were kept in check while sales grew. However the pace of expansion was limited to the company’s proprietary medicines division. Sandoz, its generics business, had flat sales for the year as volume growth was more than offset by a decline in prices. In a statement on 2 February, Novartis said it is exploring several options for Sandoz, including a separation of the business. Further information is expected, at the latest, by the end of 2022.
Pharming Group NV of the Netherlands has achieve positive results from a Phase 2/3 registration-enabling study of the small molecule drug leniolisib, a candidate treatment for activated phosphoinositide 3-kinase delta (PI3K delta) syndrome, an ultra-rare primary immunodeficiency disease. The placebo-controlled study consisted of two sequential parts, the first of which was a successful dose escalation study which reported results in 2018. Results from the second part of the study, reported on 2 February, showed clinical efficacy, including a normalisation of immune dysfunction.
Ethris GmbH has raised $26.3 million in a Series B financing round to support development of messenger RNA (mRNA) therapeutics, an area of growing interest to the pharmaceutical industry. The Munich, Germany-based company has developed a technology enabling the delivery of candidate therapies directly to the respiratory system. Whereas the small number of approved RNA medicines are delivered to patients by injection, Ethris has developed nebulisation technologies for inhaled administration.
Pfizer Inc and Ionis Pharmaceuticals Inc have discontinued development of vupanorsen, an antisense oligonucleotide intended for cardiovascular risk reduction and the treatment of severe hypertriglyceridaemia, a condition characterised by high amounts of triglycerides in the blood. Announced on 31 January, the decision was taken despite favourable results from a recent Phase 2b study.
The US Food and Drug Administration has approved the first bispecific antibody medicine for the eye – a treatment that targets two pathways thought to contribute to vision loss by destabilising blood vessels. The drug, Vabysmo (faricimab-svoa), has been authorised for the treatment of neovascular or ‘wet’ age-related macular degeneration (AMD) and diabetic macular oedema. Both diseases impair central vision, with the latter affecting people with Type 1 and Type 2 diabetes.
The cell-based gene therapy Breyanzi (lisocabtagene maraleucel) has received a positive opinion from the European Medicines Agency to treat patients with relapsed or refractory large B-cell lymphoma. Breyanzi was approved for the same indication in the US in 2021. It will be available to patients in the EU once the European Commission issues a marketing authorisation.
Data from four Phase 3 trials of faricimab, an experimental bispecific antibody for two eye diseases, were published online in The Lancet on 24 January, showing that the treatment delivered vision gains for patients that were at least as good as those achieved for aflibercept (Eylea), a widely prescribed ocular treatment. At the same time, faricimab required less frequent injections, according to the studies. Two of the trials enrolled patients with wet age-related macular degeneration and two enrolled patients with diabetic macular oedema.