A monoclonal antibody being developed by GlaxoSmithKline Plc and Genmab A/S for the treatment of patients with chronic lymphocytic leukaemia (CLL) has failed to meet its primary endpoint of progression-free survival in a small subset of patients with the disease.
Eisai Co Ltd said that real-world data for its epilepsy drug Fycompa (perampanel) show that the treatment is “generally effective and well tolerated” in a variety of patient populations including those with highly refractory epilepsy and comorbidities.
The European Medicines Agency’s main scientific committee is recommending approval of a second new treatment for hepatitis C virus infection that doesn’t require co-administration with interferon. Daklinza (daclatasvir) is the latest in a new class of direct-acting antivirals.
ThromboGenics NV of Belgium has announced a decision to continue as a stand-alone company and pursue discussions over a potential partnership for its ophthalmic medicine Jetrea in the US. This follows a strategic review that included the option of selling the company.
Roche has announced plans to create a second start-up company with the venture capital firm Versant Ventures – this time focused on the development of potential small molecule drugs for patients with multiple sclerosis.
A Phase 3 study of the checkpoint inhibitor nivolumab in patients with advanced melanoma has been stopped early because of evidence that the antibody treatment was achieving superior overall survival compared with the control arm which was chemotherapy.
Marseille, France-based Innate Pharma SA has raised €50 million from a private share placement with institutional investors which will cover its cash needs until the end of 2017, a period during which it will progress five Phase 2 trials of its checkpoint inhibitor NKG2A.
ArGEN-X BV has launched its previously-announced initial public offering of shares on the Euronext exchange in Brussels for €40 million, an amount that may be increased to €46 million on demand. In addition, there is an over-allotment option.
GW Pharmaceuticals Plc, which develops and sells cannabinoid medicines, has arranged a $169.7 million offering of its American Depositary Shares (ADSs) in which six of the company’s eight directors sold ADSs valued at $43.4 million.
The German diagnostics company Definiens AG has raised €15 million from a syndicate co-led by Wellington Partners in order to support development of new tissue-based diagnostic tests for oncology and immunotherapy.