A Phase 3 development programme for the prospective osteoarthritis drug fulranumab has been stopped early by Janssen Research & Development because of a change in strategic priorities. The decision was not based on any safety issues, the company said.
Following a review of its staff disciplinary board, the Karolinska Institutet (KI) announced on 23 March that it had dismissed Paolo Macchiarini, a surgeon who is the focus of an investigation over alleged misconduct involving a novel trachea replacement procedure.
The failure of the anti-platelet agent Brilinta (ticagrelor) to perform better than aspirin in a late-stage stroke trial has dashed expectations, at least for the time being, of expanding the approved indications for the drug.
A new once daily formulation of the HIV-1 medicine Isentress (raltegravir) has shown statistical non-inferiority to the marketed version of the same drug, paving the way for possible registration in both the US and Europe, according to Merck & Co. Inc.
Romosozumab, a monoclonal antibody that targets the protein sclerostin, has reduced the incidence of new spinal fractures in postmenopausal women with osteoporosis, according to results from a new Phase 3 study. The data were reported by UCB SA and Amgen Inc on 22 February.
Galapagos NV has stopped clinical development of a candidate drug for ulcerative colitis (UC), a form of inflammatory bowel disease, because it failed to show efficacy in a Phase 2a study. The compound targets the G-coupled protein receptor 84 (GPR84).
Abingworth LLP, the London-based investment group, has created a new fund to invest in late-stage life science assets that are being developed by two of its portfolio companies under contract with the pharmaceutical industry.
Galapagos NV and AbbVie Inc have announced progress in their cystic fibrosis drug collaboration and restated their goal of developing a combination therapy for patients with the most common genetic defect – the Delta F508 mutation.
A volunteer in a Phase 1 trial of a novel neurological therapy, who had been declared brain dead three days ago, died on Sunday, according to the drug’s developer Bial-Portela & Ca. SA of Portugal. Five other patients who took part in the trial remained hospitalised.
Encouraging early data for a new drug in patients with HIV infection has been reported by France-based ABIVAX SA, a publicly listed company with two candidate products in clinical development.