France-based Innate Pharma SA said data from a Phase 1 study of its antibody lirilumab administered with nivolumab to patients with refractory solid tumours, showed a similar safety profile to that of nivolumab alone. The data were presented on 9 October at ESMO.
A study by clinicians at the Universities of Leuven and Ghent in Belgium, together with the University of Oxford, has shown that better use of a point-of-care diagnostic can help general practitioners determine which children need hospitalisation because of a serious disease and which can remain at home.
Sanofi SA has received a second multi-million dollar contract from the US government’s biomedical advanced research and development authority (BARDA) for research into new medicinal products – this time for a product to treat acute radiation syndrome in the event of a public health emergency.
Alnylam Pharmaceutials Inc, the world’s leading developer of therapies based on RNA interference (RNAi) , has stopped development of revusiran, a treatment for a hereditary amyloidosis with cardiomyopathy, a condition caused by the abnormal accumulation of amyloid proteins in the body.
A collaborative research project between scientists at the University of Texas MD Anderson Cancer Center and Karus Therapeutics Ltd, a venture capital-backed company in the UK, has yielded a candidate drug inhibiting P13K, a target of growing interest to the pharmaceutical industry.
AstraZeneca Plc’s anti-platelet agent Brilinta (ticagrelor) has failed to show a significant benefit over Plavix in a Phase 3 study of patients with symptomatic peripheral artery disease (PAD) – the second trial failure this year for the drug.
A new combination therapy trial designed to test kinase and checkpoint inhibitors together to see whether they are effective in treating mesothelioma, non-small cell lung and pancreatic cancers, is expected to start late this year or early in 2017.
Bavarian Nordic A/S and Janssen Pharmaceutical are progressing their vaccine technology against the Ebola virus with plans to start a human study in a second-generation multivalent vaccine for Ebola and two other related viruses.
A study of patients with chronic obstructive pulmonary disease (COPD) who were treated with a new GlaxoSmithKline Plc medicine compared with the standard of care, has shown a benefit for the new medicine in everyday clinical practice.
The European Medicines Agency is recommending a tightening of its guideline on first-in-human clinical trials to provide better protections for volunteers and a new approach to evaluating protocols that cover a number of different study parts.