News

Galapagos NV has reported positive topline data from an early clinical trial of a small molecule antagonist of GPR84 in patients with idiopathic pulmonary fibrosis. The placebo-controlled study enrolled 68 patients but was not powered to show statistical significance. Nevertheless, patients receiving the treatment GLPG1205 on top of a standard of care showed a smaller decline in forced vital capacity, a measure of lung function, than those receiving a placebo and standard of care.

Moderna Inc is poised to make regulatory filings in the US and Europe today for its Covid-19 vaccines. This follows the release of new data from a Phase 3 study showing that the messenger RNA (mRNA) vaccine achieved an efficacy rate of 94.1%. The placebo-controlled study involves 30,000 participants.

The German biotech Adrenomed AG has raised €22 million from existing investors to carry forward studies of adrecizumab, its clinical stage monoclonal antibody for the treatment of septic shock. The company is due to present new efficacy data for the compound at a conference on 2 to 4 December.

Destiny Pharma Plc has raised £10.4 million from a share placement and open offer which will finance the acquisition of an anti-infective asset shown to have promise in preventing infection from the bacteria Clostridium difficile. The new shares are to be listed on the AIM market of the London Stock Exchange.

AstraZeneca Plc is to further evaluate the dosing for its candidate Covid-19 vaccine AZD1222 in light of interim data from trials in the UK and Brazil showing different efficacy rates for different dosing regimens. The data were disclosed on 23 November and showed vaccine efficacy of 90% when given as a half dose followed by a full dose at least one month apart. An efficacy rate of 62% was achieved when given as two full doses at least one month apart.

Genmab A/S has stopped development of enapotamab vedotin, an antibody-drug conjugate being investigated for the treatment of solid tumours after early clinical data did not meet the company’s criteria. “While enapotamab vedotin has shown some evidence of clinical activity, this was not optimised by different dose schedules and/or predictive biomarkers,” the company said on 24 November.

ReNeuron Group Plc has raised £15 million in a share placement with investors enabling it to expand an ongoing study of a cell therapy for retinitis pigmentosa as well as support work with exosomes. The placement was conducted on the AIM market in London and the results were announced on 24 November.

Entrepreneurs from Belgium, the Netherlands and the US have joined forces to develop a treatment that might dampen the hyperactive immune responses experienced by patients with Covid-19 associated acute respiratory distress syndrome. These cytokine storms arise when potentially lethal amounts of cytokines and chemokines are released by the body in response to viral infections. The goal is to treat these inflammatory reactions efficiently and safely.

Two European cell therapy companies have decided to merge in order to create a pipeline of allogeneic cell therapies directed against both solid and blood-borne tumours. The merger will see Sweden-based Immunicum AB take control of DCprime BV of the Netherlands through the issuance of 74 million shares valued at about SEK 600 million (€59 million). DCprime’s majority shareholder, Van Herk Investments BV, will hold approximately 43% of the combined company. Together, the new entity is expected to have funding to support product development into the beginning of 2022.

AstraZeneca Plc and the University of Oxford have become the third developers to report high levels of efficacy for their experimental vaccine to prevent Covid-19. The partners are now preparing for regulatory submissions, and have reaffirmed a commitment to supply their vaccine globally on a not-for-profit basis for the duration of the pandemic.