Anjarium Biosciences AG, a Swiss company with technology for delivering gene therapies to patients without the use of a viral vector, has raised CHF 55.5 million (€50.96 million) from a group of investors co-led by Gimv and Abingworth LLP. The money will be used to expand the company’s staff and advance several of its programmes towards the clinic.
France-based Coave Therapeutics (formerly Horama SAS) has entered into a licensing deal, giving Théa Open Innovation, an ophthalmology company, rights to co-develop and commercialise a gene therapy for retinitis pigmentosa.
AbbVie Inc has acquired rights to a gene therapy in development by Regenxbio Inc for wet age-related macular degeneration (AMD) which the companies say has potential as a one-time treatment for the disease. The therapy’s viral vector encodes an antibody fragment which is expressed inside the body to inhibit vascular endothelial growth factor (VEGF).
Netherlands-based AM-Pharma BV has reached an agreement with Kyowa Kirin Co Ltd giving that company exclusive development and commercialisation rights in Japan to its lead product, ilofotase alfa, for sepsis-associated acute kidney injury. The deal, announced on 8 September, is valued at up to €245 million including potential milestone payments.
Eli Lilly and Company is to make an equity investment in a small Dutch company that has a proprietary RNA editing technology currently directed at eye diseases but with potential for treating other disorders. ProQR Therapeutics NV of the Netherlands is to receive an equity investment of $30 million as well as a $20 million upfront payment, to support the research and development of potential new medicines for genetic disorders in the liver and nervous system.
Sanofi SA is to acquire Kadmon Holdings Inc of the US for $1.9 billion, adding a recently Food and Drug Administration-approved treatment for chronic graft-versus-host disease (cGVHD) to its transplant portfolio. The acquisition, announced on 8 September, has been unanimously approved by the boards of both companies.
Sanofi’s transplant portfolio currently consists of Thymoglobulin (anti-thymocyte globulin), an antibody preparation that acts as a broad immunosuppressive and immunomodulating agent, and Mozobil (plerixafor), an haematopoietic stem cell mobiliser.
Adaptimmune Therapeutics Plc has expanded its presence in the field of allogeneic cell therapy under a collaboration with Genentech aimed at developing new medicines for cancer. Originally founded to research T cell receptor (TCR) technology for autologous applications, Adaptimmune has recently been branching out into allogeneic, or ‘off-the-shelf’ therapies.
Owlstone Medical Ltd of the UK has raised $58 million in a Series D financing round to advance its diagnostics services for cancer and inflammatory and infectious diseases. The core technology is based on a sensor that can be programmed into software to detect biomarkers of disease in human breath.
A private equity consortium has made an $8.1 billion takeover bid for Swedish Orphan Biovitrum AB (Sobi) which has a portfolio of marketed and experimental treatments for rare diseases as well as haemophilia. Announced on 2 September, the bid has been approved by the Sobi Board of Directors and is being recommended to shareholders. The acceptance period for the offer starts on 22 September and is expected to conclude on 21 October. The consortium includes Advent International Corp and Aurora Investment Pte Ltd, an affiliate of Singapore’s sovereign-wealth fund GIC Pte Ltd.
The European Union and AstraZeneca Plc have reached a settlement on the supply of Vaxzevria, the company’s Covid-19 vaccine, to the union ensuring that vaccine deliveries through March 2022 will meet the terms of an advance purchase agreement concluded on 27 August 2020.