Eli Lilly and Company has announced a decision to stop Phase 3 development of pomaglumetad methionil for schizophrenia after a futility analysis showed that the second of two studies was unlikely to reach its primary endpoint.
Eli Lilly and Company is to seek advice from regulators about the possible next step for its investigative Alzheimer’s treatment, solanezumab, following the failure of two Phase 3 trials in patients with mild-to-moderate forms of the disease.
Mologen AG of Germany is expediting discussions with potential pharmaceutical company partners with a view towards starting a Phase 3 study of its lead product for colorectal cancer next year. The product, MGN1703, is a toll-like receptor 9 agonist.
A new allogeneic cell therapy has shown promise in the treatment of venous leg ulcers, a condition caused by persistently high blood pressure in the veins of the legs. Results from a 2b study of the therapy were published online in The Lancet on 3 August 2012.
Roche said that its angiogenesis inhibitor, Avastin (bevacizumab), has shown a significant improvement in progression-free survival in newly diagnosed glioblastoma when added to radiation and temozolomide. Overall survival data are expected in 2013.
4SC AG has been taking scientific advice from regulators about the design of a prospective Phase 3 study of its HDAC inhibitor for liver cancer, resminostat. Pending the conclusion of a partnership, a study could start in the 2013 first half, according to management.
Amgen has stopped a Phase 3 trial of its monoclonal antibody for metastatic pancreatic cancer after the independent data monitoring committee concluded the drug was unlikely to show improved overall survival compared with gemcitabine.
A second experimental treatment for severe sepsis, a significant area of unmet medical need, has been discontinued following the failure of a proof-of-concept trail. AstraZeneca Plc has stopped development of AZD9773, an anti-TNF-alpha antibody fragment.
Agennix AG is set to restructure after the surprise failure of a Phase 3 trial of its lead product for non-small cell lung cancer, talactoferrin alfa (talactoferrin). The trial did not meet its primary endpoint of improving overall survival, despite promising earlier data.
Johnson & Johnson Inc and Pfizer Inc have announced the termination of their jointly-run investigation of the drug, bapineuzumab, for patients with mild-to-moderate Alzheimer’s disease. This follows the failure of two Phase 3 studies.