A Phase IV study of bosentan has failed to show that the drug significantly prolongs time to first morbidity or mortality in patients with pulmonary arterial hypertension (PAH) already receiving sildenafil. Bosentan (Tracleer) is marketed by Actelion Pharmaceuticals Ltd.
Amgen Inc said that its oncolytic virus product, talimogene laherparepvec (TVEC), reduced the size of tumours in patients with metastatic melanoma during a recent Phase 3 trial. The data comes from a retrospective analysis of nearly 4,000 tumour lesions.
An experimental medicine for patients with polycythemia vera, a rare blood cancer, has met is primary endpoint in a global Phase 3 trial conducted by Novartis. The treatment Jakavi (ruxolitinib) is an inhibitor of the JAK 1 and JAK 2 tyrosine kinases.
Roche has told a scientific meeting in San Diego that its candidate antibody for patients with severe uncontrolled asthma and high levels of periostin has shown promising results in two Phase 2b studies. The antibody, lebrikizumab, targets IL-13.
Merck & Co Inc said told a scientific meeting in San Diego that its candidate immunotherapy for house dust mite allergy showed a significant dose-and time-dependent reduction in a nasal symptom score. The therapy is called MK-8237.
Genmab A/S said that its partner, Janssen Biotech Inc, is set to begin a Phase 3 study of its monoclonal antibody targeting CD38 in patients with relapsed multiple myeloma. Daratumumab has received ‘breakthrough therapy’ designation from the FDA.
Roche has announced that the data monitoring committee overseeing its Phase 3 study of onartuzumab for patients with MET-positive non-small lung cancer has recommended that the study be stopped due to a lack of “clinically meaningful efficacy.”
Eli Lilly and Company’s experimental drug for Type 2 diabetes, dulaglutide, has met its primary endpoint of non-inferiority in a Phase 3 trial where it was being compared with Novo Nordisk’s Victoza. Both drugs are glucagon-like peptide 1 (GLP-1) receptor agonists.
An observational study of up to 10,000 patients with suspected coronary artery disease is underway with the goal of finding new biomarkers and disease-related pathways for use in the development of diagnostic tools and treatments for cardiovascular disease.
Eli Lilly and Company said that its antibody therapy, ramucirumab, has improved overall survival in patients with non-small cell lung cancer in a global Phase 3 trial. Ramucirumab inhibits the vascular endothelial growth factor receptor 2.