Lilly’s orforglipron meets endpoints
Eli Lilly and Co’s investigational obesity drug, orforglipron, achieved a weight loss of 10.5% at the highest dose in a third Phase 3 trial whose results were reported on 3 September. Orforglipron is small molecule glucagon-like peptide-1 (GLP-1) receptor agonist designed to be taken once per day without restrictions on food and water. It differs from Lilly’s first approved weight-loss drug Zepbound (tirzepatide) which is a polypeptide drug, administered subcutaneously and intended to be taken with a diet and exercise.