Research & University News

A team of scientists at the VIB research institute and KU Leuven in Belgium has discovered that an amyloid-beta precursor protein, APP, modulates neuronal signal transmission by binding to a specific receptor called GABA_BR1a. This has implications for treating Alzheimer’s disease and probably other disorders.

Scientists at the University of Cambridge have identified mechanisms by which mutations in the ATM gene can lead to cancer drug resistance and how this can be counteracted by changes in other genes. The findings, reported on 8 January 2019 in Nature Communications, show how cells respond to DNA damage as well as highlight potential therapeutic targets for the genetic disease, ataxia-telangiectasia (A-T).

A Chinese scientist’s reported use of the Crispr gene editing tool to alter a gene in two  embryos which were implanted into a mother’s womb has created an uproar in the scientific community. The edit was performed when the embryos were just a day old and involved alterations to the CCR5 gene in order to prevent the offspring from contracting HIV. They were reported on YouTube videos, rather in a scientific journal, after twin girls bearing the DNA changes were born.

Two scientists who identified proteins which act as a break on the immune system have been awarded the 2018 Nobel Prize in Physiology or Medicine for their discovery, which is the scientific basis for the ‘immune checkpoint’ class of medicines. James P. Allison, who discovered CTLA-4, and Tasuku Honjo, who discovered PD-1, were cited by the Nobel Assembly at Karolinska Institutet for their landmark work in the global fight against cancer.

Scientists from University College London have identified a second source of endothelial cells that line the interior of blood vessels, potentially opening up a path for exploring the use of stem cells to grow new blood vessels and repair damaged ones.

A study published in the journal Science on 7 September 2018 gives new insights into how exercise can improve memory and possibly help prevent or treat Alzheimer’s disease. The corollary is that pharmaceutical treatments might be designed to mimic this effect.

Research carried out by scientists at the Technical University of Munich (TUM) in Germany suggests that colon cancer is stimulated by cell stress and bacteria and not by inflammation, as previously thought.

A study in Plos Biology by researchers from the Helmholtz Zentrum München and the Ludwig-Maximilians-Universität München has described a metabolic network in mice that is not controlled by the brain but rather by the ‘circadian clock’ inside muscle cells.

Scientists in Vienna, Austria have used organoid technology to grow brain tumours in the laboratory, enabling them to replicate the process of brain carcinogenesis, potentially making the discovery of new biomarkers and treatments for these cancers easier.

A study published in the journal Clinical Cancer Research concludes that elevated levels of kidney injury molecule-1 (KIM-1), a transmembrane protein in blood plasma, can predict renal cell carcinoma (RCC) incidence up to five years before a diagnosis.