Sanofi SA has expanded a collaboration with Innate Pharma SA giving it access to new assets in the field of natural kill (NK) cell antibody development. The French multinational has been working with Innate since 2016 and will now have rights to a programme targeting an immune checkpoint molecule known as B7H3 which is overexpressed in a number of solid tumours. Sanofi will also have an option to add up to two additional molecules to its repertoire of cancer targets.
Germany-based BioNTech SE, which together with Pfizer Inc commercialised the first Covid-19 vaccine, has entered into a partnership with the UK government to research and develop mRNA vaccines for other diseases. The multi-year collaboration will include the development of vaccines for cancer and infectious diseases. For cancer, the goal is to be able to provide personalised cancer therapies for up to 10,000 patients by the end of 2030, either in clinical trials or as authorised treatments.
Ipsen SA has announced a merger agreement with Albireo Pharma Inc which will give it a marketed product for the treatment of rare diseases affecting the liver. The acquisition is expected to provide immediate revenue from sales of Albireo’s lead drug Bylvay (odevixibat). However, given ongoing research and developments costs, it will be dilutive to Ipsen’s operating profit until the end of 2024.
AstraZeneca Plc is taking steps to strengthen its position in therapies for cardiovascular and and kidney diseases with the acquisition of CinCor Pharma Inc, a US based company whose lead product, baxdrostat, is in clinical development for blood pressure lowering. The transaction is expected to create new opportunities for treating uncontrolled hypertension as well as chronic kidney disease. In particular, baxdrostat could be combined with Farxiga, an approved medicine for diabetes, heart failure and kidney disease, AstraZeneca said on 9 January.
GSK Plc is to develop oligonucleotide therapeutics under a new collaboration with the genetic medicines company Wave Life Sciences Ltd. The agreement, which includes an upfront payment of $170 million in cash and equity as well as future milestone payments, involves the discovery and development of medicines based on genetic targets.
The oligonucleotide medicines are short DNA or RNA molecules that can modulate RNA through several mechanisms. The primary function of RNA is to create proteins via translation. The Wave technology is capable of editing, splicing and silencing RNA.
The developers of the first chimeric antigen receptor (CAR) T cell therapies are to merge their assets under a deal that they say will speed up manufacturing and create new opportunities for treating solid tumours. The deal involves the acquisition of Tmunity Therapeutics Inc of Philadelphia, US, by Kite Pharma, a business unit of Gilead Sciences Inc. The financial terms of the transaction were not disclosed.
Plans to develop a candidate therapy for solid tumours using a T cell receptor (TCR) approach were disclosed on 2 December by Immunocore Holdings Plc, which has concluded an oncology collaboration with Gadeta BV of the Netherlands. The two companies are at different stages of development, but they share an interest in using TCRs as agents for fighting disease.
TCRs are a group of proteins found on T cells that bind to certain antigens on cancer cells causing T cells to attack the malignancy.
A competition between US and French multinationals for ownership of Horizon Therapeutics Plc ended on 12 December with an all-cash offer of $27.8 billion from Amgen Inc for the Ireland-based company. The deal value is the largest healthcare merger of 2022, according to The Wall Street Journal. Sanofi SA, which also held talks with Horizon, dropped out of the discussions saying that the target company’s price expectations were too high.
C4X Discovery Holdings Plc of the UK has secured a licensing deal with AstraZeneca Plc to apply its small molecule drug discovery technology to identify new treatments for inflammatory and respiratory diseases. The initial plan is to develop a product to treat chronic obstructive pulmonary disease (COPD).
Cancer Research Horizons, a division of the UK charity Cancer Research UK, is to work with the Karolinska Institutet over the next five years to identify new opportunities for cancer treatments and move these projects forward through industrial partnerships.