Finance, Grants, Deals

TILT Biotherapeutics Ltd has raised €22.6 million from the European Innovation Council and other investors to bring its oncolytic virus therapy for patients with ovarian cancer into Phase 2. The funding will also support earlier studies for the product, TILT-123, in other indications.  TILT-123 is an oncolytic adenovirus encoding tumour necrosis factor alpha and interleukin 2. It is designed to work alongside T cell therapies and immune checkpoint inhibitors to target and kill cancer cells.

Novartis is to pay up to $1.7 billion to buy Regulus Therapeutics Inc of San Diego, US, in a deal that will strengthen its portfolio of treatments for kidney disease. The deal also puts a spotlight on microRNA, a drug target that affects gene expression without coding for a protein. Regulus has an early clinical stage product for autosomal dominant polycystic kidney disease, a serious genetic disorder that can lead to end-stage renal disease. The product, farabursen, is an oligonucleotide designed to inhibit a microRNA known as miR-17.

Isomorphic Labs Ltd, a pioneer in the use of artificial intelligence for drug discovery, announced a capital raise of $600 million on 31 March, the company’s first external financing since its launch in 2021. Isomorphic is a spin-out of the DeepMind laboratory of Alphabet Inc, the parent of Google, and led by Demis Hassabis, a Nobel laureate. DeepMind is the developer of the AlphaFold artificial intelligence programme. Isomorphic will use the new funds to develop a portfolio of drugs both in-house and in partnership with Novartis and Eli Lilly and Co.

The UK biotech Epsilogen has significantly expanded its repertoire of antibody technologies with the acquisition of TigaTx Inc, of Boston, US, in order to treat more patients with cancer. The deal, announced on 7 April, equips Epsilogen, a clinical-stage company, with technology and assets of the IgA antibody subtype. These activate neutrophils, a type of white blood cell that is an essential part of the immune system. Epsilogen already has IgG antibody assets, the most abundant subtype, and IgE assets, a less common isotype which can activate macrophages.

GSK Plc has entered into a licensing agreement with ABL Bio Inc of South Korea for rights to a delivery platform for carrying prospective drugs across the blood-brain barrier to treat neurodegenerative diseases. The deal, valued at up to £2.15 billion, is one of the company’s largest transactions, reflecting its interest in treating diseases of the brain.

A prospective vaccine against infection from the Nipah virus moved closer to clinical development on 21 March with the award of $13.38 million from the Coalition for Epidemic Preparedness Innovations (CEPI). The new grant follows $3.6 million in funding in 2023, bringing total cash available to $16.98. CEPI, a public-private partnership, is working with Gennova Biopharmaceuticals Ltd of India and the US-based Houston Methodist Research Institute on the project, which will deliver a self-amplifying messenger RNA (mRNA) vaccine to the market.

MaaT Pharma SA of France expects to make its first regulatory submission to the European Medicines Agency in June following a successful Phase 3 trial of its microbiome therapy and a capital increase of €13 million from a private share placement. The capital increase was announced on 27 March, not long after the company reported the latest clinical data for its therapy. The therapy, MaaT013, is being developed for patients with acute graft-versus-host disease with gastrointestinal involvement. 

Owlstone Medical Ltd is to receive an equity investment of up to $2.3 million from the US Cystic Fibrosis Foundation to develop a new breath test to detect a bacterial infection in patients with cystic fibrosis. The UK company has developed technology that can detect biological information from volatile organic compounds and respiratory droplets in breath. The newest project will involve developing a test for Pseudomonas aeruginosa, a Gram negative bacterial infection that can be particularly dangerous for people with compromised immune systems.

Novo Holdings A/S and Jeito Capital have co-led a new financing for Augustine Therapeutics NV of Belgium to support clinical development of the company’s candidate treatment for Charcot-Marie-Tooth disease, an inherited disorder that can cause nerve damage. The oversubscribed Series A financing raised a total of €78 million which includes an earlier sum of €17.5 million generated in 2024. Altogether 11 investors supported the company, including the US-based Charcot-Marie-Tooth Research Foundation. The closing of the Series A round was announced on 24 March.

A new biotech company has been launched in Seattle, US, and Singapore, with the goal of advancing the technology for antibody-drug conjugates - treatments for cancer that use an antibody and linker to deliver a cytotoxic agent to cancer cells. The company, Callio Therapeutics Inc, is developing ADCs that would be equipped with more than one cytotoxic payload. The company says this structure could increase the efficacy of ADCs, a drug class which is attracting developers across the industry.