Finance, Grants, Deals

Repron Therapeutics Srl, a start-up biotech company with epigenetic silencing technology, was launched on 14 April following the completion of a €2 million seed financing round led by Claris Ventures of Turin, Italy. Based in Milan, Repron was founded by Vania Broccoli and Alessandro Sessa, both affiliated with San Raffaele Hospital, the largest private hospital group in Italy. The seed investment is expected to accelerate the development of the epigenetic platform which has been designed to silence oncogene networks in order to repress tumour recurrence in several cancer indications.

Neuromod Devices Ltd of Ireland has raised €30 million in financing to support the further commercialisation of its device for the treatment of tinnitus, a medical condition in which a person experiences ringing in one or both ears which isn’t caused by an external source. The funding consists of a €15 million expansion of an earlier Series B round and €15 million in venture debt from the European Investment Bank. The Series B extension was led by Panakès Partners of Milan, Italy.

Switzerland-based Alentis Therapeutics AG has completed a Series C financing of $105 million to support the development of antibody therapeutics to treat cancer and fibrosis, rounding out the next stage in its anti claudin-1 development programme. Claudins are a group of membrane proteins that are essential for cell growth and differentiation. One of these proteins, claudin-1, is a target of considerable interest in the scientific community.

Novo Nordisk A/S is to collaborate with the Canadian biotech company Aspect Biosystems Ltd to use bioprinting technology to advance its work in cell therapies for diabetes and obesity. Novo is a leading producer of insulins and more recently glucagon-like peptide 1 medicines for the treatment of diabetes. It has also been building a presence in regenerative medicine.

Bicycle Therapeutics Plc has entered a strategic collaboration with Novartis to pair its peptide technology with Novartis’ experience in radiopharmaceutical development to design new therapies for cancer. The agreement was announced on 28 March and will include a $50 million upfront payment to Bicycle and milestone commitments of up to $1.7 billion. Bicycle’s molecules are synthetic peptides held in place with small molecule scaffolds to form two loops that stabilise the structure. This creates a small binding site for its therapies which are said to achieve very specific targeting.

The Austrian biotech company Proxygen GmbH has executed a new collaboration with a large pharma company to identify and develop compounds that can promote the degradation of disease-causing proteins. Known as molecular glue degrader therapies, these small molecule drugs accomplish their task by stabilising protein to protein interactions in the cell, enabling ubiquitin ligases to mark faulty or misfolded proteins for degradation.

Germany-based mbiomics GmbH has raised €13 million in a Series A financing round to accelerate development of microbiome-based medicines. These are live bacterial therapeutics derived from the gut that can potentially be directed against multiple diseases.

Cancer Research UK has entered into a clinical development collaboration with UCB SA of Belgium to advance two candidate antibody therapeutics for cancer into the clinic. Financial details of the partnership were not disclosed.

The deal is one of several involving the UK charity and its division Cancer Research Horizons with institutions and companies across Europe. In November 2022, Cancer Research UK reached an agreement with the Karolinska Institutet in Sweden to validate novel drug targets in cancer.

Bank regulators in the US and UK took further steps on 12 March to protect depositors at Silicon Valley Bank in California and its UK subsidiary following the collapse of the parent company the previous Friday. The US Federal Deposit Insurance Corporation (FDIC) acted first on 10 March by closing the parent bank after a run on deposits. Concurrently, it created a new banking entity to protect insured depositors. This move protected customers with accounts of up to $250,000 – the US federally insured level – but it did not stop the contagion.

Sanofi SA is to acquire Provention Bio Inc of the US giving it a marketed product, Tzield (teplizumab), that has been shown to delay the onset of type 1 diabetes, as well as a pipeline of prospective therapies for other auto-immune diseases. The France-based multinational will pay $25 per share in cash for the Nasdaq-listed company, representing an equity value of about $2.9 billion. A traditional supplier of insulin, Sanofi stepped back from investment in diabetes products in 2019 after seeing an erosion of its market share in the US.