Company News

A venture capital fund set up in 2018 to invest in early-stage companies with novel antibiotic programmes is to dispense nearly $12 million to companies in France and the US. They are Mutabilis SA, which is developing antibacterials against Gram-negative infections and IBT Vaccines, a subsidiary of Integrated Biotherapeutics Inc, which has an experimental vaccine for Staphylococcus aureus in development.

Mutabilis of Romainville, France will receive €7 million ($7.83 million) and IBT of Rockville, Maryland, US will receive $3.9 million.

Preclinical data from tests of an experimental vaccine for solid tumours have shown complete tumour regression of transplanted human tumours in mice, according to the vaccine’s developer BioNTech SE. The RNA vaccine was designed to drive the expansion of an autologous CAR T cell therapy in vivo, thereby enabling the cell therapy to infiltrate solid tumours. Results of the study were published in Science on 2 January.

Expedeon AG has completed the sale of its proteomics and immunology business to Abcam Plc of the UK for €120 million, leading to a repositioning of the company as a provider of genomics services. Based in Heidelberg, Germany, Expedeon will in future focus on manufacturing DNA for use in gene therapies and gene-based vaccines. It will henceforth go by the name 4basebio AG and will continue to be listed on the Frankfurt Stock Exchange.

Lynparza (olaparib) has been approved in the US as a first-line maintenance treatment for metastatic pancreatic cancer, the first therapy of its type to show a statistically significant improvement in progression-free survival in patients with the disease. The Food and Drug Administration announced the approval on 30 December on the basis of data from a Phase 3 trial of 154 patients who had germline BRCA-mutated pancreatic cancer.

Patients will be eligible for the drug based on an FDA-approved companion diagnostic.

Syncona Ltd has committed $80 million in new capital to Freeline Therapeutics Ltd which has a candidate gene therapy for haemophilia B in early clinical development. The Series C financing consists of two tranches, of which the first $40 million is being dispensed to support an expansion of manufacturing and clinical development activities, Freeline announced on 19 December.

France-based Truffle Capital has raised €250 million for a new life science fund that will invest in medical technologies using minimal intervention to treat major diseases such as heart disease. The closing of the BioMedTech fund was announced on 18 December. It is one of two new Truffle ventures, the second being a €140 million fund for banking and insurance innovation.

Three European biotech companies have received loans totalling €100 million from the European Investment Bank (EIB) enabling them to advance imaging and cell and gene therapy technologies, as well as individualised medicines for cancer. The EIB is the long-term lending institution of the European Union and owned by the EU member states. The three biotech companies are France-based Median Technologies SA, Italy-based MolMed SpA and Germany-based BioNTech SE.

The Roche group has acquired commercialisation rights, outside the US, for an experimental gene therapy for Duchenne muscular dystrophy, a rare degenerative neuromuscular disorder. The deal was announced on 23 December and is with Sarepta Therapeutics Inc. It comes only days after Roche received regulatory clearance to acquire the gene therapy company Spark Therapeutics Inc.

Genmab A/S has expanded its antibody repertoire under a new research and collaboration agreement with CureVac AG to produce antibody therapeutics for cancer that have been developed using messenger RNA (mRNA) technology. The agreement includes an upfront payment of $10 million for the first product and a €20 million equity investment in CureVac, as well as options on three other programmes. The deal was announced on 19 December 2019.

Boehringer Ingelheim GmbH has encountered a setback in its plans to develop multiple products for non-alcoholic steatohepatitis (NASH). A small molecule drug in-licensed from Pharmaxis Ltd in Australia is being dropped from development because of the risk of drug interactions, the German company said on 18 December.