Research & University News

Sygnis says Phase 2 stroke trial fails

In another set-back for developers of potential stroke treatments, Sygnis Pharma AG  said its Phase 2 study of a growth factor for acute ischaemic stroke failed to meet its primary and secondary endpoints. The product is a recombinant version of granulocyte colony-stimulating factor (G-CSF).

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Location

Germany

Neovacs completes enrolment for immunotherapy trial

Neovacs SA of France has completed the recruitment of patients for the first phase of a multicentre Phase 2 trial of its immunotherapy for Crohn’s disease. The primary objective will be to evaluate the ability of the therapy to induce clinical remission.

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Location

France

Ablynx in Phase 1 study of therapy for RSV

Ablynx NV has started a Phase 1 study in healthy volunteers of an antibody-derived therapeutic protein for the treatment of respiratory syncytial viral infections. To date, there is only one approved antibody therapeutic for this disease.

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Location

Belgium

Gene therapy shows benefit in patients with haemophilia B

Researchers from University College London and colleagues have reported the successful administration of a gene therapy to patients with haemophilia B. The study appears in the 10 December New England Journal of Medicine.

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Location

United Kingdom

Transplantation of bioartificial trachea reported

A team of European researchers has reported the successful transplantation of a synthetic trachea into a patient with tracheal cancer using a scaffold which was seeded with the patient’s own stem cells.

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Location

Sweden

EMBL raises €40 million for early life science

Early-stage life science projects received another boost on Wednesday with the launch of a new technology fund by the venture capital arm of the European Molecular Biology Laboratory (EMBL). The new fund, EMBL Technology Fund II, has raised €40 million in a first closing.

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Location

Germany

Zealand Pharma reports on lixisenatide trial

Zealand Pharma A/S said that the latest clinical data for its prospective type 2 diabetes treatment, lixisenatide (Lyxumia) in combination with long-acting insulin, showed a significant reduction in plasma glucose concentrations (HbA1c).

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Location

Denmark

AstraZeneca to donate compounds to UK academia

AstraZeneca Plc has announced plans to make 22 compounds available to medical researchers in the UK free of charge in a bid to promote more drug discovery. The compounds are not the focus of current research at the company.

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Location

United Kingdom

Addex reports on signalling pathways implicated in diabetes

Scientists working for Addex Pharmaceuticals Ltd of Switzerland have reported discovering an apparently novel interaction between two members of the G-protein coupled receptor (GPCR) family which may have implications for the treatment of diabetes.

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Location

Switzerland

Galapagos reports data on JAK inhibitor

Galapagos NV has become the latest company to report positive clinical data for an oral Janus kinase (JAK) inhibitor in rheumatoid arthritis, an autoimmune disease that is estimated to affect about 1% of the world’s population. Current treatments include non-steroidal anti-inflammatory drugs; methotrexate, and biologic medicines.

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Location

Belgium

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