Research & University News

Conference Report: How Europe can do better in life science

It is something of a truism to say that money follows success. It is less easy to say why some companies are more successful than others, and how their successes can be repeated.

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Location

Belgium

MedImmune and Inserm to collaborate

The AstraZeneca Plc unit, MedImmune, has entered into a three-year collaboration with the technology transfer arm of France’s National Institute of Health and Medical Research (Inserm) to research disease and potential drug candidates.

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Location

France

Amgen lung cancer trial fails to meet primary endpoint

A Phase-3 study of motesanib, a small molecule antagonist of vascular endothelial growth factor (VEGF) receptors, failed to meet its primary endpoint of improving the overall survival for patients with advanced, non-squamous, non-small cell lung cancer (NSCLC), the sponsor said.

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Location

United States

Roche reports on hedgehog pathway inhibitor

The Roche group said that its investigational hedgehog pathway inhibitor, vismodegib, which is being developed to treat advanced basal cell carcinoma, met its primary endpoint of overall response in a pivotal Phase 2 clinical study.

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Location

Switzerland

Gene therapy achieves a milestone in Parkinson’s disease

A Phase 2 study of a gene therapy for Parkinson’s disease has met its primary endpoint for efficacy and demonstrated safety. The results have been published on-line in The Lancet Neurology, according to the sponsor, Neurologix Inc.

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Location

United States

Otelixizumab fails in diabetes trial

Tolerx Inc and GlaxoSmithKline Plc announced that a Phase 3 trial of otelixizumab for patients with new-onset Type 1 diabetes did not meet the primary efficacy endpoint of change in C-peptide, a marker of beta cell function, at 12 months.

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Location

United States

Aflibercept fails in NSCLC trial

Sanofi-Aventis SA and its partner, Regeneron Pharmaceuticals Inc, have announced that their Phase 3 trial of the candidate drug, aflibercept, for second-line treatment of non-small cell lung cancer, combined with docetaxel, did not extend overall survival.

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Location

France

Généthon and Wake Forest collaborate on gene therapy project

Généthon, a not-for profit French biotherapy laboratory, has announced a collaboration with the Wake Forest University School of Medicine in the US to work on the preclinical development of a gene therapy for myotubular myopathy.

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Location

France

Scientists report transforming stem cells into neurons critical for memory

Scientists from the Northwestern University Feinberg School of Medicine in the US have reported transforming human embryonic stem cells into a type of neuron that plays a critical role in memory. The findings have been published in Stem Cells.

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Location

United States

Molecular switch for epidermal stem cells reported

Researchers at Children’s Hospital in Boston, Massachusetts have reported finding a regulator of gene activity that can instruct epidermal stem cells to grow or stop growing, a finding that may have use for cancer as well as regenerative medicine.

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Location

United States

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