Research & University News

GSK starts Phase 3 melanoma trials

GlaxoSmithKline Plc has announced the start of two Phase 3 studies that will evaluate the effectiveness of a new combination therapy for the treatment of patients with BRAF-positive metastatic cutaneous melanoma. The studies will also look at safety.

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Location

United Kingdom

Lundbeck reports on trial of AD drug

H. Lundbeck A/S said that its experimental treatment for Alzheimer’s disease, Lu AE58054, met its primary endpoint in a Phase 2 proof-of-concept study of 278 patients with moderate disease already being treated with donepezil. Full data will be disclosed at upcoming medical meetings.

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Location

Denmark

Ensemble and Genentech to collaborate on macrocyclic drugs

Ensemble Therapeutics Corporation and Genentech (Roche) have entered into a collaboration to discover new drug candidates using the US company’s macrocyclic technology platform. Financial terms were not disclosed.

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Location

United States

Karolinska and GE Healthcare to collaborate on cell therapy

The Karolinska University Hospital and GE Healthcare Life Sciences have started a joint research collaboration to address some of the issues associated with the manufacture and development of new cell therapies. Financial terms weren’t given.

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Location

Sweden

IMI launches €223.7 million antibiotic project

The European Commission and the pharmaceutical industry have committed €223.7 million to research new antibiotic medicines in the first of several projects to be carried under the Innovative Medicines Initiative (IMI).

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Location

Belgium

Nexavar lung cancer trial does not meet primary endpoint

A Phase 3 trial of Nexavar (sorafenib) in patients with advanced, relapsed non-small cell lung cancer has failed to meet its primary endpoint of improving overall survival, according to Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals Inc.

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Location

United States

Lundbeck reports positive data for MDD drug

H. Lundbeck A/S said that top-line results from three recently completed Phase 3 trials of its investigational drug for major depressive disorder, Lu AA21004, showed statistically significant reductions in depression symptoms in patients.

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Location

Denmark

Roche stops dalcetrapib trial

The Roche group has stopped a Phase 3 trial of dalcetrapib, a novel treatment for patients with dyslipidemia due to the lack of clinically meaningful efficacy. The decision was taken on the recommendation of the data and safety monitoring board.

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Location

Switzerland

Novartis says new drug is better than old

Novartis said that a Phase 3 trial of its new drug for acromegaly, pasireotide, is superior to the current standard of care for the disease. The current standard of care, Sandostatin (octreotide), is an older Novartis medicine.

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Location

Switzerland

Probiodrug reports research finding

New research has been published in Nature suggesting that the peptide pyroglutamate amyloid beta may play a crucial role in the initiation of Alzheimer’s disease. The research was conducted by scientists at Probiodrug AG and their academic partners.

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Location

Germany

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